2006
Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants
Koukouritaki S, Poch M, Henderson M, Siddens L, Krueger S, VanDyke J, Williams D, Pajewski N, Wang T, Hines R. Identification and Functional Analysis of Common Human Flavin-Containing Monooxygenase 3 Genetic Variants. Journal Of Pharmacology And Experimental Therapeutics 2006, 320: 266-273. PMID: 17050781, DOI: 10.1124/jpet.106.112268.Peer-Reviewed Original Research
2005
Discovery of Novel Flavin-Containing Monooxygenase 3 (FMO3) Single Nucleotide Polymorphisms and Functional Analysis of Upstream Haplotype Variants
Koukouritaki S, Poch M, Cabacungan E, McCarver D, Hines R. Discovery of Novel Flavin-Containing Monooxygenase 3 (FMO3) Single Nucleotide Polymorphisms and Functional Analysis of Upstream Haplotype Variants. Molecular Pharmacology 2005, 68: 383-392. PMID: 15858076, DOI: 10.1124/mol.105.012062.Peer-Reviewed Original ResearchConceptsFlavin-containing monooxygenasesFunctional analysisSingle nucleotide polymorphism (SNP) discoveryMembrane interaction domainHaplotype variantsSite-directed mutagenesisConsensus splice sitesFMO3 expressionUpstream SNPsGene functionPolymorphism discoveryNear complete lossRossmann foldFAD bindingInteraction domainSingle nucleotide polymorphismsRegion haplotypesHaplotype 8Exon SNPsFMO enzymesPromoter activityIntron SNPSequence analysisSNP frequenciesLuciferase constructHaplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics
Krueger S, Siddens L, Henderson M, Andreasen E, Tanguay R, Pereira C, Cabacungan E, Hines R, Ardlie K, Williams D. Haplotype and functional analysis of four flavin-containing monooxygenase isoform 2 (FMO2) polymorphisms in Hispanics. Pharmacogenetics And Genomics 2005, 15: 245-256. PMID: 15864117, PMCID: PMC1351039, DOI: 10.1097/01213011-200504000-00008.Peer-Reviewed Original ResearchMeSH KeywordsAllelesAntithyroid AgentsDNA PrimersDNA, ComplementaryEthylenethioureaGenetic VectorsGenotypeHaplotypesHispanic or LatinoHomozygoteHumansMethimazoleMutagenesis, Site-DirectedMutationOxygenasesPharmacogeneticsPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Single NucleotidePolymorphism, Single-Stranded ConformationalTemperatureConceptsSingle nucleotide polymorphismsInactive proteinProtein variantsSingle-strand conformation polymorphismFunctional analysisActive proteinStrand conformation polymorphismNucleotide polymorphismsFunctional impactProteinAllelesHaplotype determinationConformation polymorphismMajor alleleHaplotypesPolymorphismFMO2Minor alleleFlavinVariants