2007
Mechanisms Regulating Human FMO3 Transcription
Klick D, Hines R. Mechanisms Regulating Human FMO3 Transcription. Drug Metabolism Reviews 2007, 39: 419-442. PMID: 17786630, DOI: 10.1080/03602530701498612.Peer-Reviewed Original ResearchConceptsGC-box binding proteinsHepG2 cellsPromoter characterizationLiver nuclear proteinsNuclear proteinsTransient expressionFMO enzymesDevelopmental expressionBinding proteinTranscriptionAdult regulationProteinSpecific mechanismsEnzymeExpressionCellsNFYMajor roleYY1USF1Oxidative drugsHeterodimersMonooxygenasesReporterIsoforms
2005
Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver
Duanmu Z, Weckle A, Koukouritaki S, Hines R, Falany J, Falany C, Kocarek T, Runge-Morris M. Developmental Expression of Aryl, Estrogen, and Hydroxysteroid Sulfotransferases in Pre- and Postnatal Human Liver. Journal Of Pharmacology And Experimental Therapeutics 2005, 316: 1310-1317. PMID: 16339912, DOI: 10.1124/jpet.105.093633.Peer-Reviewed Original ResearchConceptsHuman liver cytosolImmunoreactive protein levelsHuman liverSULT2A1 expressionPostnatal liver samplesProtein levelsLiver cytosolPostnatal human developmentAdult human liverSemiquantitative Western blot analysisWestern blot analysisThird trimesterPostnatal ageEarly gestationEstrogen inactivationSulfotransferase expressionPostnatal lifeInterindividual variabilityPrenatal periodMale liverDifferent developmental profilesSULT1A1 expressionGestationLiverHydroxysteroid sulfotransferases
2003
Developmental Expression of the Major Human Hepatic CYP3A Enzymes
Stevens J, Hines R, Gu C, Koukouritaki S, Manro J, Tandler P, Zaya M. Developmental Expression of the Major Human Hepatic CYP3A Enzymes. Journal Of Pharmacology And Experimental Therapeutics 2003, 307: 573-582. PMID: 12975492, DOI: 10.1124/jpet.103.054841.Peer-Reviewed Original ResearchHuman Hepatic CYP2E1 Expression during Development
Johnsrud E, Koukouritaki S, Divakaran K, Brunengraber L, Hines R, McCarver D. Human Hepatic CYP2E1 Expression during Development. Journal Of Pharmacology And Experimental Therapeutics 2003, 307: 402-407. DOI: 10.1124/jpet.103.053124.Peer-Reviewed Original ResearchConceptsPostnatal ageDays of ageNeonatal samplesOlder infantsCYP2E1 contentHepatic CYP2E1 expressionDays postnatal ageHuman hepatic microsomesHuman fetal liverInfants 31CYP2E1 protein contentGestational ageThird trimesterPostnatal dataGreat intersubject variationCYP2E1 expressionCYP2E1 substratesAge groupsFetal samplesCYP2E1Hepatic microsomesFetal liverInfantsYoung adultsIntersubject variationHuman hepatic CYP2E1 expression during development.
Johnsrud E, Koukouritaki S, Divakaran K, Brunengraber L, Hines R, McCarver D. Human hepatic CYP2E1 expression during development. Journal Of Pharmacology And Experimental Therapeutics 2003, 307: 402-7. PMID: 14500779, DOI: 10.1124/jpet.102.053124.Peer-Reviewed Original ResearchConceptsPostnatal ageNeonatal samplesThird trimesterOlder infantsIncreasing gestational ageDays postnatal ageHuman fetal liverCYP2E1 contentDays of ageImmunodetectable CYP2E1Gestational ageHuman hepatic microsomesSecond-trimesterPostnatal dataFetal liverFetal samplesHepatic CYP2E1 expressionDecreased clearanceInfantsCYP2E1 expressionIntersubject variationCYP2E1CYP2E1 protein contentAge groupsCYP2E1 substrates
2002
Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression
Koukouritaki S, Simpson P, Yeung C, Rettie A, Hines R. Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression. Pediatric Research 2002, 51: 236-243. PMID: 11809920, DOI: 10.1203/00006450-200202000-00018.Peer-Reviewed Original ResearchConceptsFlavin-containing monooxygenasesExpression patternsSpecies-specific expression patternsFMO3 expressionTemporal expression patternsMajor adult isoformFMO genesPotential control mechanismsDevelopmental expressionProtein levelsAdult isoformsWestern blottingExpressionEmbryosNumerous therapeuticsIsoformsMonooxygenases 1Most individualsFMO3Microsomal fractionHuman liver samplesIntermediate levelsControl mechanismsGenesPrecise timing
1986
Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes
Mathis J, Prough R, Hines R, Bresnick E, Simpson E. Regulation of cytochrome P-450c by glucocorticoids and polycyclic aromatic hydrocarbons in cultured fetal rat hepatocytes. Archives Of Biochemistry And Biophysics 1986, 246: 439-448. PMID: 2870681, DOI: 10.1016/0003-9861(86)90490-x.Peer-Reviewed Original Research