2015
Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression
McCullough S, Bowers E, On D, Morgan D, Dailey L, Hines R, Devlin R, Diaz-Sanchez D. Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression. Toxicological Sciences 2015, 150: 216-224. PMID: 26719369, PMCID: PMC4838038, DOI: 10.1093/toxsci/kfv324.Peer-Reviewed Original ResearchConceptsChromatin modificationsH3 lysine 4 trimethylationSpecific chromatin modificationsChromatin modification statesLysine 4 trimethylationUnmodified H3Human bronchial epithelial cellsModification statesTotal H3H3K27 acetylationCellular signalsGene inductionPrimary human bronchial epithelial cellsKey regulatorGene expressionEpigenetic markersBronchial epithelial cellsTraditional toxicological paradigmModification levelsRelative abundanceAir-liquid interface modelTrimethylationEpithelial cellsH3Specific modifications
2011
Hepatic differentiation of amniotic epithelial cells
Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade A, Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro T, Tahan V, Skvorak K, Ellis E, Badylak S, Davila J, Hines R, Laconi E, Strom S. Hepatic differentiation of amniotic epithelial cells. Hepatology 2011, 53: 1719-1729. PMID: 21374689, PMCID: PMC3103747, DOI: 10.1002/hep.24255.Peer-Reviewed Original ResearchMeSH KeywordsAmnionAnimalsCell DifferentiationCells, CulturedEpithelial CellsHepatocytesHumansMiceMice, Inbred C57BLConceptsHuman amniotic epithelial cellsRat amniotic epithelial cellsHepatocyte-like cellsAmniotic epithelial cellsEpithelial cellsEmbryonic stem cellsExtracellular matrix proteinsStem cell-derived hepatocytesProgeny of cellsSCID/beige miceCell-derived hepatocytesGerm layersAdult liver tissueLiver genesMatrix proteinsGene characteristicsHepatic differentiationStem cellsFunctional hepatocytesNoncontroversial sourceProtein expressionEndodermal originLiver diseaseMature hepatocytesBeige mice