2008
The ontogeny of drug metabolism enzymes and implications for adverse drug events
Hines R. The ontogeny of drug metabolism enzymes and implications for adverse drug events. Pharmacology & Therapeutics 2008, 118: 250-267. PMID: 18406467, DOI: 10.1016/j.pharmthera.2008.02.005.Peer-Reviewed Original ResearchConceptsAdverse drug eventsDrug eventsDrug metabolism enzymesDME groupPediatric patientsThird trimesterCurrent knowledgeFirst trimesterDrug therapyDrug dispositionPharmacokinetic modelLow levelsEnzyme levelsTrimesterEnzyme expressionGestationSecond groupFetusesMetabolism enzymesBirthPhysiological factorsDevelopmental expression patternsMinimal changesReviewGroupRegulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition
Hines R, Koukouritaki S, Poch M, Stephens M. Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 2008, 40: 263-301. PMID: 18464046, DOI: 10.1080/03602530801952682.Peer-Reviewed Original ResearchConceptsRegulatory polymorphismsRegulatory sequencesHuman proteinsSelection pressureGene expressionCo-dominant traitEvolutionary perspectiveXenobiotic metabolismEnvironmental changesToxicant dispositionUnexpected paucityCurrent understandingHeterozygous stateTraitsPolymorphismSuch variationExpressionKnowledge gapsGenesProteinFitnessSequenceMetabolismVariationDrug disposition
2003
Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?
Lash L, Hines R, Gonzalez F, Zacharewski T, Rothstein M. Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile? Journal Of Pharmacology And Experimental Therapeutics 2003, 305: 403-409. PMID: 12606672, DOI: 10.1124/jpet.102.039925.Peer-Reviewed Original ResearchConceptsSpecific enzyme systemsExperimental Biology meetingTransgenic technologyGenetic determinantsEnzyme systemGenetic profileToxic chemicalsGeneticsDivision of ToxicologyComplex interplayHuman healthIndividual susceptibilityPharmacogenomicsExperimental therapeuticsPhysiologySusceptibilityChemicalsDivisionTherapeutics
2001
Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors.
Hines R, Luo Z, Cresteil T, Ding X, Prough R, Fitzpatrick J, Ripp S, Falkner K, Ge N, Levine A, Elferink C. Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors. Drug Metabolism And Disposition 2001, 29: 623-33. PMID: 11302926.Peer-Reviewed Original ResearchConceptsDevelopmental-specific expressionSignal transduction pathwaysMolecular regulationTransduction pathwaysCommon signal transduction pathwayReceptor-mediated signal transduction pathwaysRegulation of xenobioticGenome levelTranscription factorsMolecular mechanismsMolecular biologyEndogenous factorsGenesRegulatory systemXenobiotic-metabolizing enzymesEnzymeRegulationExpressionCytochrome P450Fundamental rolePathwayRapid proliferationTissueBiologyExperimental therapeutics