2011
Hepatic differentiation of amniotic epithelial cells
Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade A, Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro T, Tahan V, Skvorak K, Ellis E, Badylak S, Davila J, Hines R, Laconi E, Strom S. Hepatic differentiation of amniotic epithelial cells. Hepatology 2011, 53: 1719-1729. PMID: 21374689, PMCID: PMC3103747, DOI: 10.1002/hep.24255.Peer-Reviewed Original ResearchConceptsHuman amniotic epithelial cellsRat amniotic epithelial cellsHepatocyte-like cellsAmniotic epithelial cellsEpithelial cellsEmbryonic stem cellsExtracellular matrix proteinsStem cell-derived hepatocytesProgeny of cellsSCID/beige miceCell-derived hepatocytesGerm layersAdult liver tissueLiver genesMatrix proteinsGene characteristicsHepatic differentiationStem cellsFunctional hepatocytesNoncontroversial sourceProtein expressionEndodermal originLiver diseaseMature hepatocytesBeige mice
2003
Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile?
Lash L, Hines R, Gonzalez F, Zacharewski T, Rothstein M. Genetics and Susceptibility to Toxic Chemicals: Do You (or Should You) Know Your Genetic Profile? Journal Of Pharmacology And Experimental Therapeutics 2003, 305: 403-409. PMID: 12606672, DOI: 10.1124/jpet.102.039925.Peer-Reviewed Original ResearchConceptsSpecific enzyme systemsExperimental Biology meetingTransgenic technologyGenetic determinantsEnzyme systemGenetic profileToxic chemicalsGeneticsDivision of ToxicologyComplex interplayHuman healthIndividual susceptibilityPharmacogenomicsExperimental therapeuticsPhysiologySusceptibilityChemicalsDivisionTherapeutics
1995
In vitro binding and functional studies comparing the human CYPIAI negative regulatory element with the orthologous sequences from rodent genes
Boucher P, Hines R. In vitro binding and functional studies comparing the human CYPIAI negative regulatory element with the orthologous sequences from rodent genes. Carcinogenesis 1995, 16: 383-392. PMID: 7859371, DOI: 10.1093/carcin/16.2.383.Peer-Reviewed Original ResearchConceptsNegative regulatory elementSpecific DNA-protein complexesDNA-protein complexesTransient expression assaysRegulatory elementsNuclear proteinsMouse fragmentsHeterologous promoterExpression assaysCell linesElectrophoretic mobility shift assaysMouse nuclear proteinMouse CYP1A1 geneSouthwestern blot analysisMobility shift assaysCYP1A1 geneNegative regulatory activitySimilar protection patternMouse hepatoma cell lineRodent cell linesCytosine-rich sequencesCytosine-rich regionsHuman CYP1A1 geneOrthologous sequencesRodent genes
1993
Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector
States J, Quan T, Hines R, Novak R, Runge-Morris M. Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector. Carcinogenesis 1993, 14: 1643-1649. PMID: 8353849, DOI: 10.1093/carcin/14.8.1643.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideAnimalsBase SequenceBenzo(a)pyreneBenzoflavonesBiotransformationCadmiumCadmium CompoundsChimeraCytochrome P-450 Enzyme SystemDNA RepairEnzyme InductionFibroblastsGene Expression Regulation, EnzymologicGenetic VectorsHumansIsoenzymesMiceMolecular Sequence DataPlasmidsRNA, MessengerSulfatesTransfectionTransformation, GeneticXeroderma PigmentosumConceptsCytochrome P450 1A1P450 1A1Inducible CYP1A1Inducible mouse metallothionein-I promoterLow dosesHuman skin fibroblastsProficient cellsPotent mutagenic agentCYP1A1 expressionCYP1A1 activityHuman cytochrome P450 1A1DNA repairCYP1A1Mouse metallothionein-I promoterCytotoxic effectsMetallothionein-I promoterSkin fibroblastsDifferential cytotoxicityDNA repair-proficient cellsToxic effectsMore cytotoxicCytochrome P450Normal cellsRepairHuman CYP1A1
1988
Identification of multiple regulatory elements on the human cytochrome P450IA1 gene
Hines R, Mathis J, Jacob C. Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 1988, 9: 1599-1605. PMID: 3409463, DOI: 10.1093/carcin/9.9.1599.Peer-Reviewed Original Research
1987
Aflatoxin B1-4-hydroxylase is associated with cytochrome P3-450 in C57BL6 mouse liver
Koser P, Faletto M, Bansal S, Caballes L, Bresnick E, Hines R, Gurtoo H. Aflatoxin B1-4-hydroxylase is associated with cytochrome P3-450 in C57BL6 mouse liver. Biochemical And Biophysical Research Communications 1987, 142: 872-878. PMID: 3103616, DOI: 10.1016/0006-291x(87)91494-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAroclorsAryl Hydrocarbon HydroxylasesBenzoflavonesBeta-NaphthoflavoneChlorodiphenyl (54% Chlorine)Cytochrome P-450 Enzyme SystemDNAEnzyme InductionFemaleLiverMethylcholanthreneMiceMice, Inbred C57BLMixed Function OxygenasesNucleic Acid HybridizationPolychlorinated BiphenylsRNA, Messenger
1981
Inhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815).
Wiebkin P, Hines R, Nelson R, Prough R. Inhibition of metabolism--mediated cytotoxicity by 1,1-disubstituted hydrazines in mouse mastocytoma cells (line P815). 1981, 136 Pt B: 1067-75. PMID: 7344500.Peer-Reviewed Original Research