2001
Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells
Delescluse C, Ledirac N, Li R, Piechocki M, Hines R, Gidrol X, Rahmani R. Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochemical Pharmacology 2001, 61: 399-407. PMID: 11226373, DOI: 10.1016/s0006-2952(00)00562-1.Peer-Reviewed Original ResearchMeSH KeywordsCarbarylChloramphenicol O-AcetyltransferaseCholinesterase InhibitorsCytochrome P-450 CYP1A1DNA DamageEndoplasmic Reticulum Chaperone BiPEnzyme InductionGene ExpressionHeat-Shock ProteinsHumansMutagenicity TestsOxidative StressThiabendazoleTranscription, GeneticTransfectionTumor Cells, CulturedConceptsXenobiotic responsive elementStress genesChloramphenicol acetyl transferase (CAT) reporter geneAcetyl transferase reporter geneLevel of transcriptionTransferase reporter geneOxidative stressCell linesHuman hepatoma HepG2 cell lineHuman lymphoblastoid cell linesTranscriptional regulationHepatoma HepG2 cell lineCytochrome P450 1A1 gene expressionReporter CATTranscriptional levelReporter geneXRE sequenceLymphoblastoid cell linesGene expressionFusion constructsIntracellular signalsParental linesCYP1A1 cDNAResponse elementResponsive element
1998
Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.
Piechocki M, Hines R. Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity. Carcinogenesis 1998, 19: 771-780. PMID: 9635862, DOI: 10.1093/carcin/19.5.771.Peer-Reviewed Original Research
1994
Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor
Thomsen J, Wang X, Hines R, Safe S. Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis 1994, 15: 933-937. PMID: 8200098, DOI: 10.1093/carcin/15.5.933.Peer-Reviewed Original ResearchConceptsMDA-MB-231 cellsHuman breast cancer cellsMDA-MB-231 human breast cancer cellsAh-responsivenessBreast cancer cellsNM TCDDHuman estrogen receptor expression plasmidAryl hydrocarbon responsivenessCancer cellsReceptor expression plasmidAryl hydrocarbon receptorProgesterone receptorEstrogen receptorResponsive plasmidCYP1A1 gene expressionHydrocarbon receptorReceptorsCell linesCYP1A1 geneCAT activityExpression of nuclearParallel studyHuman CYP1A1 geneCellsExpression plasmid
1991
Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors
THOMSEN J, NISSEN L, STACEY S, HINES R, AUTRUP H. Differences in 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin‐inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans‐acting factors. The FEBS Journal 1991, 197: 577-582. PMID: 2029891, DOI: 10.1111/j.1432-1033.1991.tb15946.x.Peer-Reviewed Original Research