2006
Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model
Yang F, Tong X, McCarver D, Hines R, Beard D. Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model. Journal Of Pharmacokinetics And Pharmacodynamics 2006, 33: 485-518. PMID: 16758333, DOI: 10.1007/s10928-006-9018-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnalgesics, OpioidArea Under CurveBiological AvailabilityChild, PreschoolComputer SimulationHumansHydrogen-Ion ConcentrationInfantInfant, NewbornMaleMethadoneMiddle AgedModels, BiologicalMonte Carlo MethodProtein BindingRegression AnalysisStereoisomerismTissue DistributionConceptsInter-individual variabilityPediatric populationPharmacokinetic modelMethadone kineticsPopulation-based analysisPopulation-based pharmacokineticsMetabolism of methadoneMethadone distributionMethadone metabolismMethadone pharmacokineticsOpioid abstinencePediatric patientsClinical effectsPD relationshipBlood concentrationsPlasma concentrationsLimited pharmacokineticsPharmacodynamic dataOrosomucoid concentrationPK parametersPK dataMethadonePharmacokineticsClearance kineticsPBPK model
1994
The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression
Hines R, Cashman J, Philpot R, Williams D, Ziegler D. The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression. Toxicology And Applied Pharmacology 1994, 125: 1-6. PMID: 8128486, DOI: 10.1006/taap.1994.1042.Peer-Reviewed Original ResearchConceptsFlavin-containing monooxygenaseRegulation of expressionSpecies-specific differencesFlavin-Containing MonooxygenasesMixture of cisSubstrate specificityMammalian speciesToxicant susceptibilitySoft nucleophilesMolecular characterizationEnzyme's abilitySecondary alkylMultiple tissuesEarly stepsActive derivativesEnzyme systemUnique stereoselectivityFlavin enzymesHuman FMO3Toxic intermediatesFMO expressionThiocarbamideSpeciesChemical toxicityCytochrome P450