1999
ROLE OF CANONICAL GLUCOCORTICOID RESPONSIVE ELEMENTS IN MODULATING EXPRESSION OF GENES REGULATED BY THE ARYLHYDROCARBON RECEPTOR*
LINDER M, FALKNER K, SRINIVASAN G, HINES R, PROUGH R. ROLE OF CANONICAL GLUCOCORTICOID RESPONSIVE ELEMENTS IN MODULATING EXPRESSION OF GENES REGULATED BY THE ARYLHYDROCARBON RECEPTOR*. Drug Metabolism Reviews 1999, 31: 247-271. PMID: 10065375, DOI: 10.1081/dmr-100101917.Peer-Reviewed Original ResearchAnimalsCytochrome P-450 CYP1A1Gene Expression RegulationGenes, ReporterGlucocorticoidsHumansLiverRatsReceptors, Aryl HydrocarbonRegulatory Sequences, Nucleic Acid
1998
Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity.
Piechocki M, Hines R. Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity. Carcinogenesis 1998, 19: 771-780. PMID: 9635862, DOI: 10.1093/carcin/19.5.771.Peer-Reviewed Original Research
1995
Partial Characterization of the Human CYP1A1 Negatively Acting Transcription Factor and Mutational Analysis of Its Cognate DNA Recognition Sequence
Boucher P, Piechocki M, Hines R. Partial Characterization of the Human CYP1A1 Negatively Acting Transcription Factor and Mutational Analysis of Its Cognate DNA Recognition Sequence. Molecular And Cellular Biology 1995, 15: 5144-5151. PMID: 7651431, PMCID: PMC230761, DOI: 10.1128/mcb.15.9.5144.Peer-Reviewed Original ResearchBase SequenceBinding SitesBinding, CompetitiveCells, CulturedCytochrome P-450 Enzyme SystemDNA Mutational AnalysisGene Expression Regulation, EnzymologicHumansMolecular Sequence DataNuclear ProteinsOxygenasesProtein BindingRegulatory Sequences, Nucleic AcidSequence Homology, Nucleic AcidTranscription FactorsIn vitro binding and functional studies comparing the human CYPIAI negative regulatory element with the orthologous sequences from rodent genes
Boucher P, Hines R. In vitro binding and functional studies comparing the human CYPIAI negative regulatory element with the orthologous sequences from rodent genes. Carcinogenesis 1995, 16: 383-392. PMID: 7859371, DOI: 10.1093/carcin/16.2.383.Peer-Reviewed Original ResearchConceptsNegative regulatory elementSpecific DNA-protein complexesDNA-protein complexesTransient expression assaysRegulatory elementsNuclear proteinsMouse fragmentsHeterologous promoterExpression assaysCell linesElectrophoretic mobility shift assaysMouse nuclear proteinMouse CYP1A1 geneSouthwestern blot analysisMobility shift assaysCYP1A1 geneNegative regulatory activitySimilar protection patternMouse hepatoma cell lineRodent cell linesCytosine-rich sequencesCytosine-rich regionsHuman CYP1A1 geneOrthologous sequencesRodent genes
1993
Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene
Boucher P, Ruch R, Hines R. Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene. Journal Of Biological Chemistry 1993, 268: 17384-17391. PMID: 8349622, DOI: 10.1016/s0021-9258(19)85346-2.Peer-Reviewed Original ResearchConceptsNegative regulatory activityNuclear proteinsElectrophoretic mobility shift assaysCellular trans-acting factorsTrans-acting factorsRegulatory activityStrand-specific mannerCo-transfection studiesMethylation interference experimentsMobility shift assaysNegative regulatory elementSpecific nuclear proteinCytosine-rich sequencesHuman CYP1A1 genePromoter/enhancerRegulatory elementsShift assaysTransient expressionReporter geneDNase IChimeric plasmidsCYP1A1 promoterImportant sequencesCYP1A1 genePalindromes
1988
Identification of multiple regulatory elements on the human cytochrome P450IA1 gene
Hines R, Mathis J, Jacob C. Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 1988, 9: 1599-1605. PMID: 3409463, DOI: 10.1093/carcin/9.9.1599.Peer-Reviewed Original Research