2008
Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition
Hines R, Koukouritaki S, Poch M, Stephens M. Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 2008, 40: 263-301. PMID: 18464046, DOI: 10.1080/03602530801952682.Peer-Reviewed Original ResearchConceptsRegulatory polymorphismsRegulatory sequencesHuman proteinsSelection pressureGene expressionCo-dominant traitEvolutionary perspectiveXenobiotic metabolismEnvironmental changesToxicant dispositionUnexpected paucityCurrent understandingHeterozygous stateTraitsPolymorphismSuch variationExpressionKnowledge gapsGenesProteinFitnessSequenceMetabolismVariationDrug disposition
2003
CYP2C9exon 4 mutations and warfarin dose phenotype in Asians
Rettie A, Tai G, Veenstra D, Farin F, Srinouanprachan S, Lin Y, Thummel K, Hines R. CYP2C9exon 4 mutations and warfarin dose phenotype in Asians. Blood 2003, 101: 2896-2897. PMID: 12642346, DOI: 10.1182/blood-2002-11-3452.Peer-Reviewed Original Research
2002
Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities
Park C, Kang J, Chung W, Yi H, Pie J, Park D, Hines R, McCarver D, Cha Y. Ethnic differences in allelic frequency of two flavin-containing monooxygenase 3 (FMO3) polymorphisms: linkage and effects on in vivo and in vitro FMO activities. Pharmacogenetics And Genomics 2002, 12: 77-80. PMID: 11773868, DOI: 10.1097/00008571-200201000-00011.Peer-Reviewed Original Research