2008
Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition
Hines R, Koukouritaki S, Poch M, Stephens M. Regulatory Polymorphisms and their Contribution to Interindividual Differences in the Expression of Enzymes Influencing Drug and Toxicant Disposition. Drug Metabolism Reviews 2008, 40: 263-301. PMID: 18464046, DOI: 10.1080/03602530801952682.Peer-Reviewed Original ResearchConceptsRegulatory polymorphismsRegulatory sequencesHuman proteinsSelection pressureGene expressionCo-dominant traitEvolutionary perspectiveXenobiotic metabolismEnvironmental changesToxicant dispositionUnexpected paucityCurrent understandingHeterozygous stateTraitsPolymorphismSuch variationExpressionKnowledge gapsGenesProteinFitnessSequenceMetabolismVariationDrug disposition
1995
Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.)
Peters L, Livingstone D, Shenin-Johnson S, Hines R, Schlenk D. Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.). Xenobiotica 1995, 25: 121-131. PMID: 7618340, DOI: 10.3109/00498259509061838.Peer-Reviewed Original ResearchConceptsFlavin monooxygenaseNADPH-dependent flavin monooxygenaseFMO-1Full-length cDNA probeFMO-2TMA N-oxideGene expressionMarine teleostsMature fishNorthern analysisCDNA probeXenobiotic metabolismDMA N-oxideImmunoreactive proteinOsmoregulationConversion of trimethylamineN-oxidase activityMonooxygenaseMichaelis-Menten kineticsSingle bandTurbotPiperonyl butoxideTeleostsFishProtein