2016
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
Hines R, Simpson P, McCarver D. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. Drug Metabolism And Disposition 2016, 44: 959-966. PMID: 26825642, DOI: 10.1124/dmd.115.068957.Peer-Reviewed Original ResearchConceptsHepatic carboxylesterase 1Weeks of ageCarboxylesterase 1CES2 expressionAge groupsYounger age groupsCES1 expressionLiver diseaseAdverse outcomesMetabolic clearancePmol/Older groupOlder individualsWestern blottingLiver samplesWeeksEnvironmental chemicalsPostnatal ontogenyMicrosomal proteinMedian valueAgeCytosolic fractionGroupExpressionSubjects
2011
Chloride Modulates GSTZ1 Haplotype‐dependent Inactivation by Dichloroacetate
Li W, Gu Y, Langaee T, Hines R, Stacpoole P, James M. Chloride Modulates GSTZ1 Haplotype‐dependent Inactivation by Dichloroacetate. The FASEB Journal 2011, 25: 813.2-813.2. DOI: 10.1096/fasebj.25.1_supplement.813.2.Peer-Reviewed Original ResearchGSTZ1 activityLiver cytosolHuman liver cytosolCongenital lactic acidosisHaplotype-dependent mannerLactic acidosisGSTZ1 protein expressionGSTZ1 haplotypeMM dichloroacetateDCA pharmacokineticsProtein expressionDichloroacetateHr incubationGSTZ1SubjectsKRTIndividualsHeterozygous individualsInactivationAcidosisPharmacokineticsCancerDosesClearance