1994
The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression
Hines R, Cashman J, Philpot R, Williams D, Ziegler D. The Mammalian Flavin-Containing Monooxygenases: Molecular Characterization and Regulation of Expression. Toxicology And Applied Pharmacology 1994, 125: 1-6. PMID: 8128486, DOI: 10.1006/taap.1994.1042.Peer-Reviewed Original ResearchConceptsFlavin-containing monooxygenaseRegulation of expressionSpecies-specific differencesFlavin-Containing MonooxygenasesMixture of cisSubstrate specificityMammalian speciesToxicant susceptibilitySoft nucleophilesMolecular characterizationEnzyme's abilitySecondary alkylMultiple tissuesEarly stepsActive derivativesEnzyme systemUnique stereoselectivityFlavin enzymesHuman FMO3Toxic intermediatesFMO expressionThiocarbamideSpeciesChemical toxicityCytochrome P450
1986
The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue
Iversen P, Hines R, Bresnick E. The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue. BioEssays 1986, 4: 15-19. PMID: 3790107, DOI: 10.1002/bies.950040105.Peer-Reviewed Original ResearchConceptsRegulation of expressionEnzyme systemUbiquitous familySubstrate specificityGene expressionMultiple isozymesMolecular biologyCytochrome PToxic lesionsExogenous compoundsOxidative metabolismMechanisms of metabolismExpressionInducible cytochrome PIsozymesComplete understandingMetabolismBiochemical pharmacologyOrganismsBiologySpeciesRegulationWide varietyCascadeCurrent notions
1985
3-Methylcholanthrene-induced expression of the cytochrome P-450c gene
Foldes R, Hines R, Ho K, Shen M, Nagel K, Bresnick E. 3-Methylcholanthrene-induced expression of the cytochrome P-450c gene. Archives Of Biochemistry And Biophysics 1985, 239: 137-146. PMID: 4004253, DOI: 10.1016/0003-9861(85)90820-3.Peer-Reviewed Original ResearchConceptsNuclear RNA speciesCytochrome P-450c mRNARNA speciesCytochrome P-450c geneP-450c geneClone 46Nuclear transcription systemNuclear RNA precursorsNuclear RNA transportRat serum albumin geneDot hybridization experimentsSerum albumin geneNorthern blot analysisTranscriptional controlRNA transportRNA precursorsNuclear RNARegulation of inductionHybridization experimentsTranscription systemM13 subclonesAlbumin geneCytochrome P-450cRNA inductionSpecies