2008
CYP3A4 regulation by DBP and E4BP4 transcription factors
Maas K, Le M, Hines R. CYP3A4 regulation by DBP and E4BP4 transcription factors. The FASEB Journal 2008, 22: 921.7-921.7. DOI: 10.1096/fasebj.22.1_supplement.921.7.Peer-Reviewed Original ResearchD-element binding proteinDose-dependent mannerCYP3A4 promoter activityPromoter activityLuciferase expressionCYP3A4 regulationPostnatal liverLuciferase reporterProtein 4Luciferase activityHepG2 cellsE4BP4Binding proteinDevelopmental expression patternsResponsive elementExpression patternsHigh affinityProximal promoterTranscription factorsExpressionActivity
2001
Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells
Delescluse C, Ledirac N, Li R, Piechocki M, Hines R, Gidrol X, Rahmani R. Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochemical Pharmacology 2001, 61: 399-407. PMID: 11226373, DOI: 10.1016/s0006-2952(00)00562-1.Peer-Reviewed Original ResearchMeSH KeywordsCarbarylChloramphenicol O-AcetyltransferaseCholinesterase InhibitorsCytochrome P-450 CYP1A1DNA DamageEndoplasmic Reticulum Chaperone BiPEnzyme InductionGene ExpressionHeat-Shock ProteinsHumansMutagenicity TestsOxidative StressThiabendazoleTranscription, GeneticTransfectionTumor Cells, CulturedConceptsXenobiotic responsive elementStress genesChloramphenicol acetyl transferase (CAT) reporter geneAcetyl transferase reporter geneLevel of transcriptionTransferase reporter geneOxidative stressCell linesHuman hepatoma HepG2 cell lineHuman lymphoblastoid cell linesTranscriptional regulationHepatoma HepG2 cell lineCytochrome P450 1A1 gene expressionReporter CATTranscriptional levelReporter geneXRE sequenceLymphoblastoid cell linesGene expressionFusion constructsIntracellular signalsParental linesCYP1A1 cDNAResponse elementResponsive element