2011
Chloride Modulates GSTZ1 Haplotype‐dependent Inactivation by Dichloroacetate
Li W, Gu Y, Langaee T, Hines R, Stacpoole P, James M. Chloride Modulates GSTZ1 Haplotype‐dependent Inactivation by Dichloroacetate. The FASEB Journal 2011, 25: 813.2-813.2. DOI: 10.1096/fasebj.25.1_supplement.813.2.Peer-Reviewed Original ResearchGSTZ1 activityLiver cytosolHuman liver cytosolCongenital lactic acidosisHaplotype-dependent mannerLactic acidosisGSTZ1 protein expressionGSTZ1 haplotypeMM dichloroacetateDCA pharmacokineticsProtein expressionDichloroacetateHr incubationGSTZ1SubjectsKRTIndividualsHeterozygous individualsInactivationAcidosisPharmacokineticsCancerDosesClearance
2006
Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model
Yang F, Tong X, McCarver D, Hines R, Beard D. Population-Based Analysis of Methadone Distribution and Metabolism Using an Age-Dependent Physiologically Based Pharmacokinetic Model. Journal Of Pharmacokinetics And Pharmacodynamics 2006, 33: 485-518. PMID: 16758333, DOI: 10.1007/s10928-006-9018-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAnalgesics, OpioidArea Under CurveBiological AvailabilityChild, PreschoolComputer SimulationHumansHydrogen-Ion ConcentrationInfantInfant, NewbornMaleMethadoneMiddle AgedModels, BiologicalMonte Carlo MethodProtein BindingRegression AnalysisStereoisomerismTissue DistributionConceptsInter-individual variabilityPediatric populationPharmacokinetic modelMethadone kineticsPopulation-based analysisPopulation-based pharmacokineticsMetabolism of methadoneMethadone distributionMethadone metabolismMethadone pharmacokineticsOpioid abstinencePediatric patientsClinical effectsPD relationshipBlood concentrationsPlasma concentrationsLimited pharmacokineticsPharmacodynamic dataOrosomucoid concentrationPK parametersPK dataMethadonePharmacokineticsClearance kineticsPBPK model