2016
Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny
Hines R, Simpson P, McCarver D. Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny. Drug Metabolism And Disposition 2016, 44: 959-966. PMID: 26825642, DOI: 10.1124/dmd.115.068957.Peer-Reviewed Original ResearchConceptsHepatic carboxylesterase 1Weeks of ageCarboxylesterase 1CES2 expressionAge groupsYounger age groupsCES1 expressionLiver diseaseAdverse outcomesMetabolic clearancePmol/Older groupOlder individualsWestern blottingLiver samplesWeeksEnvironmental chemicalsPostnatal ontogenyMicrosomal proteinMedian valueAgeCytosolic fractionGroupExpressionSubjects
2011
Hepatic differentiation of amniotic epithelial cells
Marongiu F, Gramignoli R, Dorko K, Miki T, Ranade A, Serra M, Doratiotto S, Sini M, Sharma S, Mitamura K, Sellaro T, Tahan V, Skvorak K, Ellis E, Badylak S, Davila J, Hines R, Laconi E, Strom S. Hepatic differentiation of amniotic epithelial cells. Hepatology 2011, 53: 1719-1729. PMID: 21374689, PMCID: PMC3103747, DOI: 10.1002/hep.24255.Peer-Reviewed Original ResearchConceptsHuman amniotic epithelial cellsRat amniotic epithelial cellsHepatocyte-like cellsAmniotic epithelial cellsEpithelial cellsEmbryonic stem cellsExtracellular matrix proteinsStem cell-derived hepatocytesProgeny of cellsSCID/beige miceCell-derived hepatocytesGerm layersAdult liver tissueLiver genesMatrix proteinsGene characteristicsHepatic differentiationStem cellsFunctional hepatocytesNoncontroversial sourceProtein expressionEndodermal originLiver diseaseMature hepatocytesBeige mice