2012
Age‐Dependent Expression of Human Drug‐Metabolizing Enzymes
Hines R. Age‐Dependent Expression of Human Drug‐Metabolizing Enzymes. 2012, 1-33. DOI: 10.1002/9780470921920.edm085.Peer-Reviewed Original Research
2002
The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes
Hines R, McCarver D. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase I Oxidative Enzymes. Journal Of Pharmacology And Experimental Therapeutics 2002, 300: 355-360. PMID: 11805191, DOI: 10.1124/jpet.300.2.355.Peer-Reviewed Original ResearchThe Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms
McCarver D, Hines R. The Ontogeny of Human Drug-Metabolizing Enzymes: Phase II Conjugation Enzymes and Regulatory Mechanisms. Journal Of Pharmacology And Experimental Therapeutics 2002, 300: 361-366. PMID: 11805192, DOI: 10.1124/jpet.300.2.361.Peer-Reviewed Original ResearchConceptsDrug-metabolizing enzyme expressionFetal liverN-acetyltransferase 1 (NAT1) activitiesPhase II conjugation enzymeHuman drug metabolizing enzymesEnzyme expressionDrug metabolizing enzymesPaucity of dataPhase II enzymesCCAAT/enhancer binding protein (C/EBP) familyHepatocyte nuclear factorSecond trimesterAdrenal glandHepatic expressionPostnatal changesNAT1 expressionFetal expressionNuclear factorUDP-glucuronosyltransferasePhase ILiverSulfotransferase isoformsRelated factorsIsoform expression patternLimited data