2003
Trichloroethylene Decreases Heat Shock Protein 90 Interactions with Endothelial Nitric Oxide Synthase: Implications for Endothelial Cell Proliferation
Ou J, Ou Z, McCarver D, Hines R, Oldham K, Ackerman A, Pritchard K. Trichloroethylene Decreases Heat Shock Protein 90 Interactions with Endothelial Nitric Oxide Synthase: Implications for Endothelial Cell Proliferation. Toxicological Sciences 2003, 73: 90-97. PMID: 12657742, DOI: 10.1093/toxsci/kfg062.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCalcimycinCattleCell DivisionCells, CulturedEndothelial CellsEnzyme InhibitorsHSP90 Heat-Shock ProteinsIonophoresNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIIPhosphorylationPrecipitin TestsSuperoxidesTrichloroethyleneVascular Endothelial Growth Factor AConceptsEndothelial cell proliferationCell proliferationNormal blood vessel growthHeat shock protein 90Shock protein 90Serine 1179Hsp90 interactionEndothelial cellsProtein 90Blood vessel growthENOS functionImportant roleProteinActivation stateInhibited VEGFVessel growthGrowth factorBalance of NONew insightsProliferationVascular endothelial growth factorNitric oxideEndothelial growth factorEndothelial nitric oxide synthaseEnvironmental pollutants
1988
Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells
Tiesman J, Meyer A, Hines R, Rizzino A. Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells. In Vitro Cellular & Developmental Biology 1988, 24: 1209-1216. PMID: 3209587, DOI: 10.1007/bf02624192.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factorGrowth factorSK-Hep-1 cellsEC cellsMouse EC cellsCarcinoma cellsHuman EC cell linesNT2/D1Basic fibroblast growth factorGrowth factor productionHeparin-binding growth factorsEmbryonal carcinoma cellsEC cell linesPDGF A-chainFibroblast growth factorHuman embryonal carcinoma cellsHuman EC cellsMouse embryonal carcinoma cellsFactor productionFGFbCell linesCDNA probeSimilar salt concentrationsCellsCurrent study