1996
Identification of tissue-specific DNase I hypersensitive sites in the rabbit flavin-containing monooxygenase form 2 gene.
Shehin-Johnson S, Palmer K, Hines R. Identification of tissue-specific DNase I hypersensitive sites in the rabbit flavin-containing monooxygenase form 2 gene. Drug Metabolism And Disposition 1996, 24: 891-8. PMID: 8869825.Peer-Reviewed Original ResearchConceptsDNase IHypersensitive sitesTissue-specific transcription factorsLambda EMBL3 genomic libraryPolyomavirus enhancer activator 3Base pairsTissue-specific DNase I hypersensitive siteDNase I hypersensitive sitesTissue-specific DNase IEMBL3 genomic libraryPrimer extension analysisTranscription start siteClassical TATA boxTissue-specific mannerHypersensitive domainGenomic clonesGenomic libraryMethylated regionsTranscription factorsCDNA sequenceKilobase pairsStart siteTATA boxExtension analysisType II cell populations
1985
Gene structure and nucleotide sequence for rat cytochrome P-450c
Hines R, Levy J, Conrad R, Iversen P, Shen M, Renli A, Bresnick E. Gene structure and nucleotide sequence for rat cytochrome P-450c. Archives Of Biochemistry And Biophysics 1985, 237: 465-476. PMID: 3838427, DOI: 10.1016/0003-9861(85)90300-5.Peer-Reviewed Original ResearchConceptsRat cytochrome P-450cRegulatory sequencesCDNA sequenceEntire geneSecond genomic cloneCommon ancestral geneGenomic blot analysisComplete cDNA sequenceIntron/exon junctionsPotential regulatory sequencesCytochrome P-450c mRNACytochrome P-450c genePartial cDNA cloneRat genomic libraryAmino acid sequenceCross-hybridization studiesGross structural differencesA fragmentGT/AGExon 2P-450c geneAncestral geneGene structureGenomic clonesCytochrome P3-450