2024
Artificial intelligence applied to electrocardiographic images for scalable screening of cardiac amyloidosis
Sangha V, Oikonomou E, Krumholz H, Miller E, Khera R. Artificial intelligence applied to electrocardiographic images for scalable screening of cardiac amyloidosis. European Heart Journal 2024, 45: ehae666.3436. DOI: 10.1093/eurheartj/ehae666.3436.Peer-Reviewed Original ResearchATTR-CMBone scintigraphy scansTransthyretin amyloid cardiomyopathyPositive predictive valueAI-ECG algorithmCardiac amyloidosisScintigraphy scanAmyloid cardiomyopathyAI-ECGSex-matchedDevelopment cohortMyocardial remodelingUnder-diagnosedUnder-treatedMatched controlsPredictive valueUnder-recognizedTransthyretin stabilizersConvolutional neural networkPatientsECGArtificial intelligenceHospitalPrevalenceTransthyretinDetection of ATTR cardiac amyloidosis using a novel artificial intelligence algorithm for wearable-adapted noisy single-lead electrocardiograms
Sangha V, Oikonomou E, Khunte A, Miller E, Khera R. Detection of ATTR cardiac amyloidosis using a novel artificial intelligence algorithm for wearable-adapted noisy single-lead electrocardiograms. European Heart Journal 2024, 45: ehae666.3438. DOI: 10.1093/eurheartj/ehae666.3438.Peer-Reviewed Original ResearchReal-world noiseSingle-lead ECGArtificial intelligence algorithmsMultiple signal-to-noise ratiosCommunity-dwelling adultsSignal-to-noise ratioIntelligence algorithmsATTR-CMMatched controlsECG signalsDevelopment cohortPreventive careHealthcare servicesBlack adultsHospital systemCommunity screeningAlgorithmBone scintigraphy scansATTR cardiac amyloidosisPrevalence levelsOnset of symptomsPositive predictive valuePrevalenceAI-ECG algorithmSex-matched
2021
Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States
Valero-Elizondo J, Chouairi F, Khera R, Grandhi GR, Saxena A, Warraich HJ, Virani SS, Desai NR, Sasangohar F, Krumholz HM, Esnaola NF, Nasir K. Atherosclerotic Cardiovascular Disease, Cancer, and Financial Toxicity Among Adults in the United States. JACC CardioOncology 2021, 3: 236-246. PMID: 34396329, PMCID: PMC8352280, DOI: 10.1016/j.jaccao.2021.02.006.Peer-Reviewed Original ResearchCost-related medication nonadherenceFinancial toxicityMedication nonadherenceNational Health Interview SurveyAtherosclerotic cardiovascular diseaseMedical billsHealth Interview SurveyCancer careASCVDCardiovascular diseaseHigh burdenHigher oddsElderly populationCancerInterview SurveyFood insecurityCareNonadherenceSignificant proportionAdultsToxicityHigh financial distressPatientsPrevalenceDiseasePrevalence of Missing Data in the National Cancer Database and Association With Overall Survival
Yang DX, Khera R, Miccio JA, Jairam V, Chang E, Yu JB, Park HS, Krumholz HM, Aneja S. Prevalence of Missing Data in the National Cancer Database and Association With Overall Survival. JAMA Network Open 2021, 4: e211793. PMID: 33755165, PMCID: PMC7988369, DOI: 10.1001/jamanetworkopen.2021.1793.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNon-small cell lung cancerOverall survivalCell lung cancerCancer DatabaseMedical recordsLung cancerProstate cancerBreast cancerPatient recordsComplete dataRetrospective cohort studyCohort studyCancer RegistryCommon cancerVariables of interestHigh prevalenceMAIN OUTCOMEPatientsClinical advancementReal-world data sourcesCancerPrevalenceSurvivalHeterogeneous differences
2020
Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases
Nguyen NH, Khera R, Ohno-Machado L, Sandborn WJ, Singh S. Prevalence and Effects of Food Insecurity and Social Support on Financial Toxicity in and Healthcare Use by Patients With Inflammatory Bowel Diseases. Clinical Gastroenterology And Hepatology 2020, 19: 1377-1386.e5. PMID: 32526341, PMCID: PMC7987215, DOI: 10.1016/j.cgh.2020.05.056.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseEmergency department useCost-related medicationFinancial toxicityBowel diseaseHealthcare useDepartment useSocial supportMedical billsInadequate social supportMultivariable analysisFood insecurityHigh financial toxicityPatientsFinancial hardshipSocial determinantsAbstractTextPopulation healthPrevalenceHealthcare deliveryMedicationsAdultsDiseaseFamily incomeToxicityAssociation of cardiovascular risk factor profile and financial hardship from medical bills among non-elderly adults in the United States
Grandhi GR, Valero-Elizondo J, Mszar R, Brandt EJ, Annapureddy A, Khera R, Saxena A, Virani SS, Blankstein R, Desai NR, Blaha MJ, Cheema FH, Vahidy FS, Nasir K. Association of cardiovascular risk factor profile and financial hardship from medical bills among non-elderly adults in the United States. American Journal Of Preventive Cardiology 2020, 2: 100034. PMID: 34327457, PMCID: PMC8315456, DOI: 10.1016/j.ajpc.2020.100034.Peer-Reviewed Original ResearchAtherosclerotic cardiovascular diseaseCardiovascular risk factor profileCost-related barriersRisk factor profileNon-elderly adultsCRF profileLow prevalenceMedical billsFactor profileNational Health Interview SurveyHealth Interview SurveyLack of insuranceFinancial hardshipLogistic regression modelsLow incomeASCVD statusRisk factorsCardiovascular diseaseStudy populationLower oddsLower mortalityUninsured individualsLow burdenHealthcare expendituresPrevalence
2019
Association of access to exercise opportunities and cardiovascular mortality
Angraal S, Gupta A, Khera R, Nasir K, Desai NR. Association of access to exercise opportunities and cardiovascular mortality. American Heart Journal 2019, 212: 152-156. PMID: 31051426, DOI: 10.1016/j.ahj.2019.02.010.Peer-Reviewed Original ResearchConceptsCVD mortalityLower CVD mortalityCardiovascular disease mortalityLeisure physical activityExercise opportunitiesAssociation of accessCardiovascular mortalityDisease mortalityHigh prevalencePhysical activityExercise facilitiesMortalityHigh accessHigh percentageLow accessObesityDiabetesPrevalence