2022
Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest
Wheelock K, Chan P, Chen L, de Lemos J, Miller P, Nallamothu B, Girotra S, Khera R. Time in therapeutic range for targeted temperature management and outcomes following out-of-hospital cardiac arrest. Resuscitation 2022, 182: 109650. PMID: 36442596, PMCID: PMC9885789, DOI: 10.1016/j.resuscitation.2022.11.016.Peer-Reviewed Original ResearchConceptsFavorable neurologic outcomeHospital cardiac arrestTherapeutic rangeNeurologic outcomeOverall survivalTemperature managementCardiac arrestFavorable neurologic survivalFavorable neurological outcomeRetrospective cohort studyTargeted temperature managementHigh therapeutic rangeRisk-adjusted analysisComatose survivorsNeurologic survivalNeurological outcomeCohort studyHospital dischargeMedian durationMedian timeCurrent guidelinesCompression trialTreatment targetsSignificant associationGoal temperatureVariation in coronary angiography use in Out-of-Hospital cardiac arrest
Agusala V, Dale P, Khera R, Brown S, Idris A, Link M, Mody P. Variation in coronary angiography use in Out-of-Hospital cardiac arrest. Resuscitation 2022, 181: 79-85. PMID: 36332772, DOI: 10.1016/j.resuscitation.2022.10.020.Peer-Reviewed Original ResearchConceptsRates of CAGEarly coronary angiographyCoronary angiographyST elevationNon-shockable rhythmTrial clustersOHCA patientsShockable rhythmInitial non-shockable rhythmHospital cardiac arrest patientsUse of CAGCoronary angiography useInitial arrest rhythmInitial shockable rhythmPost-resuscitation electrocardiogramProportion of patientsOverall study populationCardiac arrest patientsHospital cardiac arrestArrest rhythmAngiography useHospital admissionArrest patientsCardiac arrestNational cohort
2019
Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children
Khera R, Tang Y, Girotra S, Nadkarni VM, Link MS, Raymond TT, Guerguerian AM, Berg RA, Chan PS, Investigators F. Pulselessness After Initiation of Cardiopulmonary Resuscitation for Bradycardia in Hospitalized Children. Circulation 2019, 140: 370-378. PMID: 31006260, PMCID: PMC6663562, DOI: 10.1161/circulationaha.118.039048.Peer-Reviewed Original ResearchConceptsPulseless cardiac arrestHospital cardiac arrestCardiac arrestCardiopulmonary resuscitationPediatric patientsHospitalized childrenPoor perfusionHospital dischargeMinutes of CPRPredictors of survivalRate of progressionMultilevel Poisson regression modelsYears of ageRate of survivalPoisson regression modelsRisk-adjusted ratesGuidelines-ResuscitationPostresuscitation careResuscitation attemptsBradycardiaHigh riskPulseless arrestChest compressionsPulselessnessCPR eventsAssociation Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest
Khera R, Tang Y, Link MS, Krumholz HM, Girotra S, Chan PS. Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005429. PMID: 30871337, PMCID: PMC6592630, DOI: 10.1161/circoutcomes.118.005429.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAwards and PrizesFemaleGuideline AdherenceHeart ArrestHospital MortalityHospitalsHumansInpatientsMaleMiddle AgedOutcome and Process Assessment, Health CarePatient DischargePractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesResuscitationTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesYoung AdultConceptsHospital cardiac arrestCardiac arrestRate of survivalSpontaneous circulationIn-Hospital Cardiac ArrestGuidelines-Resuscitation registryCardiac arrest survivalEndotracheal tube placementHigh rateHospital performanceBest tertileGuidelines-ResuscitationNational GetGuideline adherenceOverall survivalBackground HospitalTube placementNational registryChest compressionsResuscitation qualityHospitalHospital recognitionAward statusSurvivalWeak association
2018
Intraosseous versus intravenous access in patients with out-of-hospital cardiac arrest: Insights from the resuscitation outcomes consortium continuous chest compression trial
Mody P, Brown SP, Kudenchuk PJ, Chan PS, Khera R, Ayers C, Pandey A, Kern K, de Lemos JA, Link MS, Idris AH. Intraosseous versus intravenous access in patients with out-of-hospital cardiac arrest: Insights from the resuscitation outcomes consortium continuous chest compression trial. Resuscitation 2018, 134: 69-75. PMID: 30391366, DOI: 10.1016/j.resuscitation.2018.10.031.Peer-Reviewed Original ResearchConceptsFavorable neurological functionIntravenous accessNeurological functionIntraosseous accessCompression trialHospital cardiac arrest resuscitationInitial drug administrationHospital cardiac arrestCardiac arrest resuscitationOptimal access routeDelivery of medicationsBystander cardiopulmonary resuscitationRate of survivalSustained ROSCHospital survivalInitial rhythmHospital dischargeOHCA patientsROSC rateSpontaneous circulationUnadjusted outcomesSustained returnCardiac arrestCardiopulmonary resuscitationPatientsHospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest
Khera R, Humbert A, Leroux B, Nichol G, Kudenchuk P, Scales D, Baker A, Austin M, Newgard CD, Radecki R, Vilke GM, Sawyer KN, Sopko G, Idris AH, Wang H, Chan PS, Kurz MC. Hospital Variation in the Utilization and Implementation of Targeted Temperature Management in Out-of-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2018, 11: e004829. PMID: 30571336, DOI: 10.1161/circoutcomes.118.004829.Peer-Reviewed Original ResearchConceptsTargeted temperature managementHospital cardiac arrestCardiac arrestMedian rateResuscitation Outcomes Consortium sitesHospital cardiac arrest patientsImproved functional survivalMedian hospital rateClass I recommendationPotential survival benefitResuscitation Outcomes ConsortiumNon-traumatic outCardiac arrest patientsTemperature managementPatterns of utilizationConsecutive adultsHospital arrivalProspective cohortSurvival benefitArrest patientsHospital variationI recommendationMean ageOutcomes ConsortiumResuscitation guidelinesEarly coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis
Khera R, CarlLee S, Blevins A, Schweizer M, Girotra S. Early coronary angiography and survival after out-of-hospital cardiac arrest: a systematic review and meta-analysis. Open Heart 2018, 5: e000809. PMID: 30402255, PMCID: PMC6203043, DOI: 10.1136/openhrt-2018-000809.Peer-Reviewed Original ResearchEarly coronary angiographyFavorable neurological outcomeCoronary angiographyHospital cardiac arrestNeurological outcomeCardiac arrestQ testAcute myocardial infarctionConcurrent control groupMultiple electronic databasesRandom-effects modelCochran's Q testSurvival outcomesMyocardial infarctionObservational studyCommon causePooled estimatesHigher oddsExposure groupOHCAAngiographyStudy heterogeneityControl groupElectronic databasesSystematic review
2016
Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest
Khera R, Chan PS, Donnino M, Girotra S. Hospital Variation in Time to Epinephrine for Nonshockable In-Hospital Cardiac Arrest. Circulation 2016, 134: 2105-2114. PMID: 27908910, PMCID: PMC5173427, DOI: 10.1161/circulationaha.116.025459.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestEpinephrine administrationCardiac arrestFunctional recoveryHospital variationNonshockable rhythmsHospital ratesSurvival rateRisk-standardized survival ratesIn-Hospital Cardiac ArrestHospital-level outcomesRisk-standardized ratesDose of epinephrineMedian survival rateOdds of delayHigh rateGuidelines-ResuscitationAdult patientsOverall survivalWorse survivalSimilar patientsLowest quartileImproved outcomesHospitalPatients