1996
Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas.
Piepmeier J, Susan Christopher R, Spencer D, Byrne T, Kim J, Knisel J, Lacy J, Tsukerman L, Makuch R. Variations in the natural history and survival of patients with supratentorial low-grade astrocytomas. Neurosurgery 1996, 38: 872-8; discussion 878-9. PMID: 8727811, DOI: 10.1097/00006123-199605000-00002.Peer-Reviewed Original ResearchConceptsLow-grade astrocytomasGross total resectionChronic epilepsySupratentorial low-grade astrocytomasNatural historyGross total tumor resectionImmediate postoperative radiotherapyExtent of surgerySurvival of patientsTen-year survivalPopulation of patientsUse of radiotherapyRisk of recurrenceHigh-grade lesionsLength of survivalMore malignant tumorsTypes of symptomsAggressive surgeryPostoperative radiotherapyPreoperative symptomsConsecutive patientsBetter prognosisTumor recurrenceTumor resectionMalignant tumors
1988
Identifying prognostic factors in binary outcome data: An application using liver function tests and age to predict liver metastases
Makuch R, Rosenberg P, Mulshine J. Identifying prognostic factors in binary outcome data: An application using liver function tests and age to predict liver metastases. Statistics In Medicine 1988, 7: 843-856. PMID: 2842852, DOI: 10.1002/sim.4780070803.Peer-Reviewed Original ResearchConceptsLiver function testsLiver metastasesFunction testsOutcome dataSmall cell lung cancerImportant prognostic variablesCell lung cancerLogistic regression modelsPrognostic factorsLung cancerPrognostic variablesMetastasisBinary outcome dataSpecific guidelinesRegression modelsAgeStandard logistic regression model
1984
Elevated serum creatine kinase BB levels in patients with small cell lung cancer.
Carney D, Zweig M, Ihde D, Cohen M, Makuch R, Gazdar A. Elevated serum creatine kinase BB levels in patients with small cell lung cancer. Cancer Research 1984, 44: 5399-403. PMID: 6091876.Peer-Reviewed Original ResearchConceptsSmall cell lung cancerSerum CK-BBSerum CK-BB levelsCK-BB levelsCell lung cancerMetastatic sitesLung cancerCK-BBCreatine kinase BB levelsExtensive-stage diseaseSCLC cell linesClinical tumor specimensLimited diseaseClinical responseExtensive diseaseMetastatic diseaseUntreated patientsPretreatment stagingTumor disseminationTumor specimensPatientsBB isoenzymeBb levelsSignificant associationCreatine kinaseDiagnosis and significance of liver metastases in small cell carcinoma of the lung.
Mulshine J, Makuch R, Johnston-Early A, Matthews M, Carney D, Ihde D, Cohen M, Bates H, Dunnick N, Minna J. Diagnosis and significance of liver metastases in small cell carcinoma of the lung. Journal Of Clinical Oncology 1984, 2: 733-41. PMID: 6330314, DOI: 10.1200/jco.1984.2.7.733.Peer-Reviewed Original ResearchConceptsLiver function testsLiver metastasesLiver biopsyLiver scanFunction testsLiver evaluationSmall cell lung cancerNoninvasive procedureDisease-free survivorsPercutaneous liver biopsySmall cell carcinomaCell lung cancerRadionuclide liver scanResponse of patientsNational Cancer InstituteSuch metastasesLiver involvementConsecutive patientsStaging procedureHepatic metastasesPrognostic implicationsCell carcinomaPhysical examinationLung cancerCancer Institute
1982
Carcinomatous Leptomeningitis in Small Cell Lung Cancer
ROSEN S, AISNER J, MAKUCH R, MATTHEWS M, IHDE D, WHITACRE M, GLATSTEIN E, WIERNIK P, LICHTER A, BUNN P. Carcinomatous Leptomeningitis in Small Cell Lung Cancer. Medicine 1982, 61: 45. PMID: 6276648, DOI: 10.1097/00005792-198201000-00005.Peer-Reviewed Original ResearchConceptsClinical courseSystemic diseaseSpinal cordUnivariate log-rank analysisSmall cell lung cancerProgressive systemic diseaseLog-rank analysisPatient's clinical courseSpinal cord lesionsCell lung cancerVirchow-Robin spacesLife-table analysisCNS metastasesComplete respondersExtensive diseaseIntrathecal chemotherapyLiver metastasesMedian survivalSystemic therapyComplete responseCord lesionsIntracerebral metastasesAutopsy featuresDiffuse involvementSole manifestation
1981
Peritoneoscopy in the management of ovarian cancer
Ozols R, Fisher R, Anderson T, Makuch R, Young R. Peritoneoscopy in the management of ovarian cancer. American Journal Of Obstetrics And Gynecology 1981, 140: 611-619. PMID: 6455064, DOI: 10.1016/0002-9378(81)90192-7.Peer-Reviewed Original ResearchMeSH KeywordsAbdominal NeoplasmsFeasibility StudiesFemaleFollow-Up StudiesHumansLaparoscopyLaparotomyNeoplasm StagingOvarian NeoplasmsConceptsOvarian cancerPercent of patientsResidual ovarian cancerSecond-look laparotomyNational Cancer InstituteConventional radiologicDiaphragmatic diseasePrior laparotomyMedical therapySerious complicationsSurgical explorationPeritoneoscopic findingsResidual diseasePatientsCancer InstituteLaparotomyStage IFeasible procedurePeritoneoscopyRoutine useComplicationsDiseaseCancerInitial evaluationOnly evidencePrognostic Implications of Stage of Disease and Sites of Metastases in Patients with Small Cell Carcinoma of the Lung Treated with Intensive Combination Chemotherapy1,2
Ihde D, Makuch R, Carney D, Bunn P, Cohen M, Matthews M, Minna J. Prognostic Implications of Stage of Disease and Sites of Metastases in Patients with Small Cell Carcinoma of the Lung Treated with Intensive Combination Chemotherapy1,2. American Journal Of Respiratory And Critical Care Medicine 1981, 123: 500-7. PMID: 6263137, DOI: 10.1164/arrd.1981.123.5.500.Peer-Reviewed Original ResearchConceptsSmall cell carcinomaExtensive diseaseCentral nervous systemLimited diseaseCell carcinomaBone marrowNervous systemIntensive induction chemotherapyInvolvement of boneSite of metastasisSoft tissueRadionuclide boneAggressive chemotherapyInduction chemotherapyChest roentgenogramMetastatic diseaseUntreated patientsLiver biopsyStaging procedureDistant metastasisFiberoptic bronchoscopyOpposite lungPrognostic implicationsPhysical examinationPretreatment staging
1979
Serum glycoproteins and immunoglobulins in nasopharyngeal carcinoma Correlations with Epstein-Barr virus associated antibodies and clinical tumor stage
Baskies A, Chretien P, Yang C, Wolf G, Makuch R, Tu S, Hsu M, Lynn T, Yang H, Weiss J, Spiegel H. Serum glycoproteins and immunoglobulins in nasopharyngeal carcinoma Correlations with Epstein-Barr virus associated antibodies and clinical tumor stage. The American Journal Of Surgery 1979, 138: 478-488. PMID: 225960, DOI: 10.1016/0002-9610(79)90406-9.Peer-Reviewed Original ResearchConceptsClinical tumor stageElevated antibody titersEpstein-Barr virusSerum levelsAntibody titersTumor stageAcute phase proteinsNasopharyngeal carcinomaTumor presenceImmunoglobulin levelsNormal subjectsEBV antibody titersSerum haptoglobin levelsNeck squamous carcinomaHealthy normal subjectsMonitoring of responseSerum glycoproteinsAnti-EBVUntreated patientsIgA antibodiesEarly antigenSquamous carcinomaStaging systemImmunoglobulins IgAHaptoglobin levelsSerum glycoproteins in head and neck squamous carcinoma Correlations with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy
Wolf G, Chretien P, Elias E, Makuch R, Baskies A, Spiegel H, Weiss J. Serum glycoproteins in head and neck squamous carcinoma Correlations with tumor extent, clinical tumor stage, and T-cell levels during chemotherapy. The American Journal Of Surgery 1979, 138: 489-500. PMID: 90464, DOI: 10.1016/0002-9610(79)90407-0.Peer-Reviewed Original ResearchConceptsΑ1-acid glycoprotein levelsT cell levelsTumor stageAcute phase proteinsUntreated patientsSerum levelsTumor extentCellular immunityImmune reactivitySquamous carcinomaPhase proteinsGlycoprotein levelsSpecific acute phase proteinsCompletion of chemotherapyClinical tumor stageChronic cigarette smokersΑ1-antitrypsin levelsΑ1-antitrypsinCellular immune parametersNeck squamous carcinomaPreoperative chemotherapyRecurrent carcinomaAlbumin levelsControl patientsRegional metastases