2000
Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia
Martiney J, Sherry B, Metz C, Espinoza M, Ferrer A, Calandra T, Broxmeyer H, Bucala R. Macrophage Migration Inhibitory Factor Release by Macrophages after Ingestion of Plasmodium chabaudi-Infected Erythrocytes: Possible Role in the Pathogenesis of Malarial Anemia. Infection And Immunity 2000, 68: 2259-2267. PMID: 10722628, PMCID: PMC97412, DOI: 10.1128/iai.68.4.2259-2267.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaAnimalsBone MarrowCells, CulturedDose-Response Relationship, DrugEnzyme-Linked Immunosorbent AssayErythrocytesErythroid Precursor CellsErythropoiesisErythropoietinFemaleImmunohistochemistryLeukopoiesisLiverMacrophage Migration-Inhibitory FactorsMacrophagesMalariaMiceMice, Inbred BALB CMice, Inbred C3HPlasmodium chabaudiSpleenTime FactorsConceptsMacrophage migration inhibitory factorChabaudi-infected erythrocytesMalarial anemiaP. chabaudi-infected miceBALB/c miceP. chabaudi-infected erythrocytesTumor necrosis factor alphaMacrophage migration inhibitory factor releaseHuman falciparum malariaRed blood cell destructionPlasmodium falciparum infectionMigration inhibitory factorNecrosis factor alphaSuppression of erythropoiesisAntibody neutralization studiesBlood cell destructionHost-derived factorsPlasmodium chabaudi-infected erythrocytesErythropoiesis inhibitorMalaria anemiaActive diseaseCerebral malariaChabaudi infectionFalciparum malariaFalciparum infection
1998
Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria
Calandra T, Spiegel L, Metz C, Bucala R. Macrophage migration inhibitory factor is a critical mediator of the activation of immune cells by exotoxins of Gram-positive bacteria. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 11383-11388. PMID: 9736745, PMCID: PMC21651, DOI: 10.1073/pnas.95.19.11383.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesBacterial ToxinsCell DivisionCells, CulturedDisease Models, AnimalEnterotoxinsExotoxinsGram-Positive BacteriaInflammationInterferon-gammaInterleukin-2Lymphocyte ActivationMacrophage Migration-Inhibitory FactorsMacrophages, PeritonealMicePituitary GlandShock, SepticSpleenStaphylococcusStreptococcusSuperantigensConceptsMacrophage migration inhibitory factorMigration inhibitory factorMIF secretionInhibitory factorStaphylococcal toxic shock syndrome toxin 1Toxic shock syndrome toxin-1Anti-MIF antibodiesSplenocyte cytokine productionTSST-1 injectionInterferon-gamma secretionLethal mouse modelStreptococcal pyrogenic exotoxinT cell cytokinesInnate host responseLethal toxic shockProliferation of splenocytesT-cell productsInnate immune responseSyndrome toxin-1Dose-response studyMouse peritoneal macrophagesSpleen enlargementMIF antibodyC57BL/6 miceCytokine production