2019
Immunoepidemiology of Mycobacterium tuberculosis
Odio C, Bucala R. Immunoepidemiology of Mycobacterium tuberculosis. 2019, 151-163. DOI: 10.1007/978-3-030-25553-4_9.Peer-Reviewed Original ResearchHuman leukocyte antigenMycobacterium tuberculosisLatent Mycobacterium tuberculosisRole of nutritionNumber one causeRegional infectious diseasesHuman immune systemActive diseaseVitamin DLeukocyte antigenRisk factorsDisease presentationClinical diversityInfectious agentsOne causeImmune systemHost defenseInfectious diseasesImmunoepidemiologyImmune proteinsDisease phenotypeTuberculosisInfectionDiseaseImmunological diversityChapter 83 Adaptive Immunity and Critical Illness
Schulte W, Maerz L, Moeckel G, Bucala R. Chapter 83 Adaptive Immunity and Critical Illness. 2019, 483-487. DOI: 10.1016/b978-0-323-44942-7.00083-2.Peer-Reviewed Original ResearchAcute kidney injuryCritical illnessEnd-stage renal diseaseChronic kidney diseaseChallenging clinical conditionIschemia-reperfusion injuryComplex disease processAdaptive immune systemAKI pathophysiologyKidney injuryHospitalized patientsRenal diseaseKidney diseaseInflammatory processCommon causeClinical conditionsAdaptive immunityLong-term consequencesDisease processImmune systemSubsequent treatmentInjuryIllnessDiseaseCurrent knowledge
2013
Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221)
Benedek G, Meza-Romero R, Andrew S, Leng L, Burrows G, Bourdette D, Offner H, Bucala R, Vandenbark A. Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects (P5221). The Journal Of Immunology 2013, 190: 67.4-67.4. DOI: 10.4049/jimmunol.190.supp.67.4.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorExperimental autoimmune encephalomyelitisPartial MHC class II constructsCD74 cell-surface expressionMultiple sclerosisCell surface expressionMIF/CD74 interactionMigration inhibitory factorAutoimmune encephalomyelitisAlpha 1 domainInflammatory activityProinflammatory cytokinesHistological signsMIF activityAnti-apoptotic activityImmune systemInhibitory factorEnhanced secretionMHC complexesAntigenic peptidesCD74MIF effectsRandom migrationSurface expressionPivotal regulator
2006
Immunosuppressive Factors in Cancer
Moss J, Metz C, Bucala R. Immunosuppressive Factors in Cancer. 2006 DOI: 10.1002/3527600906.mcb.200400129.Peer-Reviewed Original ResearchImmunosuppressive factorsTumor cellsHost's antitumor defenseHost immune responseHost immune systemSuccessful cancer therapeuticsCancer patientsAntitumor defenseImmune responseEffective treatmentEvasive mechanismsImmune systemCell surface receptorsCancer therapeuticsSurface receptorsCancerCellsPatientsCytokinesProstaglandinsAntigenMajor obstacleReceptors
2001
Neuroendocrine properties of macrophage migration inhibitory factor (MIF)
Fingerle‐Rowson G, Bucala R. Neuroendocrine properties of macrophage migration inhibitory factor (MIF). Immunology And Cell Biology 2001, 79: 368-375. PMID: 11488984, DOI: 10.1046/j.1440-1711.2001.01024.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorCytokine macrophage migration inhibitory factorPro-inflammatory actionsMIF expressionSeptic shockNeuroendocrine mediatorsInflammatory diseasesPathogenic roleEndocrine circuitsNeuroendocrine propertiesImmune systemEndocrine tissuesImmune tissuesNeuroendocrine mechanismsDiseaseTissueArthritisNeuroendocrineFactors
1999
Interaction of Borrelia burgdorferi with Peripheral Blood Fibrocytes, Antigen-Presenting Cells with the Potential for Connective Tissue Targeting
Grab D, Lanners H, Martin L, Chesney J, Cai C, Adkisson H, Bucala R. Interaction of Borrelia burgdorferi with Peripheral Blood Fibrocytes, Antigen-Presenting Cells with the Potential for Connective Tissue Targeting. Molecular Medicine 1999, 5: 46-54. PMID: 10072447, PMCID: PMC2230375, DOI: 10.1007/bf03402138.Peer-Reviewed Original ResearchConceptsPeripheral blood fibrocytesBlood fibrocytesDifferent cell typesB. burgdorferiB. burgdorferi bindsInteraction of BorreliaMolecular mechanismsOspB proteinsAntigen presenting cellsCell typesFibroblast-like cellsCellular interactionsCell membraneJoint connective tissuesCollagen type ILyme arthritisPresent antigensInflammatory processT cellsFunctional capacityCellular collagenImmune systemFlow cytometryFibrocytesConnective tissue
1998
Neuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF)
BUCALA R. Neuroimmunomodulation by Macrophage Migration Inhibitory Factor (MIF). Annals Of The New York Academy Of Sciences 1998, 840: 74-82. PMID: 9629239, DOI: 10.1111/j.1749-6632.1998.tb09551.x.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorImmune responseRole of MIFInhibitory factorT cell cytokine productionAnti-inflammatory propertiesAnterior pituitary cellsT-lymphocyte factorSteroid therapyLymph nodesCytokine productionImmunosuppressive effectsInflammatory conditionsGlucocorticoid actionT cellsFirst cytokineInflammatory sitesTherapeutic strategiesProinflammatory stimuliPituitary cellsImmune systemLymphocyte factorsGlucocorticoidsInhibitory effect
1997
Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System
Calandra T, Bucala R. Macrophage Migration Inhibitory Factor (MIF): A Glucocorticoid Counter-Regulator within the Immune System. Critical Reviews In Immunology 1997, 17: 77-88. PMID: 9034724, DOI: 10.1615/critrevimmunol.v17.i1.30.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCattleChickensGene Expression RegulationGlucocorticoidsHumansInterferon-gammaInterleukinsLipopolysaccharidesMacrophage Migration-Inhibitory FactorsMacrophagesMiceMolecular Sequence DataMolecular StructurePituitary GlandRatsSequence Homology, Amino AcidShock, SepticT-LymphocytesTumor Necrosis Factor-alphaConceptsMacrophage migration inhibitory factorMigration inhibitory factorImmune responseImmune systemT lymphocyte-derived factorInhibitory factorInhibitory effectLymphocyte-derived factorRecombinant MIF proteinIFN-gamma productionIL-1 betaIL-8 productionT cell proliferationAnterior pituitary glandEnigmatic cytokineLethal endotoxemiaIL-6MIF proteinIL-2TNF-alphaCounter regulatorT lymphocytesProtective effectGlucocorticoid inhibitionPituitary glandRole of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response
Metz C, Bucala R. Role of Macrophage Migration Inhibitory Factor in the Regulation of the Immune Response. Advances In Immunology 1997, 66: 197-223. PMID: 9328642, DOI: 10.1016/s0065-2776(08)60598-2.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorMigration inhibitory factorT cellsImmune responseInhibitory factorAnti-inflammatory effectsInflammatory disease statesAnterior pituitary glandSeptic shockMIF actionMIF proteinInflammatory responseGlucocorticoid actionImmune systemPituitary glandCorticotrophic cellsGlucocorticoidsInhibitory effectDisease statesBaseline statePotential roleMacrophagesCellsResponseArthritis
1996
MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid‐induced regulator of the immune response
Bucala R. MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid‐induced regulator of the immune response. The FASEB Journal 1996, 10: 1607-1613. PMID: 9002552, DOI: 10.1096/fasebj.10.14.9002552.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorImmune responseSecretion of MIFMigration inhibitory factorAnterior pituitary cellsImmune cell activationT-lymphocyte productsProfound inhibitory effectFirst cytokine activitiesCounterregulatory hormonesLymph nodesCytokine productionImmunosuppressive effectsGlucocorticoid actionLymphocyte productsT cellsPituitary hormonesInflammatory sitesCytokine activityPituitary cellsSteroid concentrationsCell activationImmune systemInhibitory factorInhibitory effectMIF re-discovered: Pituitary hormone and glucocorticoid-induced regulator of cytokine production
Bucala R. MIF re-discovered: Pituitary hormone and glucocorticoid-induced regulator of cytokine production. Cytokine & Growth Factor Reviews 1996, 7: 19-24. PMID: 8864351, DOI: 10.1016/1359-6101(96)00008-1.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorAssociation of MIFT cell-derived factorsCounter-regulatory hormonesPrimary immune responseMigration inhibitory factorCell-derived factorSource of infectionAnterior pituitary cell lineFirst cytokine activitiesLymph nodesCytokine productionGlucocorticoid actionPituitary cell lineImmune responsePituitary hormonesInflammatory sitesCytokine activityHost responseImmune systemInhibitory factorInhibitory effectTissue invasionProtein mediatorsRandom migration