2008
Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis
Neklason D, Kerber R, Nilson D, Anton-Culver H, Schwartz A, Griffin C, Lowery J, Schildkraut J, Evans J, Tomlinson G, Strong L, Miller A, Stopfer J, Finkelstein D, Nadkarni P, Kasten C, Mineau G, Burt R. Common Familial Colorectal Cancer Linked to Chromosome 7q31: A Genome-Wide Analysis. Cancer Research 2008, 68: 8993-8997. PMID: 18974144, PMCID: PMC2927856, DOI: 10.1158/0008-5472.can-08-1376.Peer-Reviewed Original ResearchConceptsGenetic regionsLinkage analysisGenome-wide analysisFamilial cancer genesNovel susceptibility genesNonparametric linkage analysisShort tandem repeat markersCommon Familial Colorectal CancerFine mappingRepeat markersTandem repeat markersCancer genesChromosome 7q31Odds (LOD) scoreGenesSusceptibility genesSignificant linkagePenetrant genesDNA samplesFamilial colorectal cancerRelative pairsLociCancer onsetColorectal cancer onsetCancer syndromes
2004
Integration of Web-based and PC-based Clinical Research Databases
Brandt CA, Sun K, Charpentier P, Nadkarni PM. Integration of Web-based and PC-based Clinical Research Databases. Methods Of Information In Medicine 2004, 43: 287-295. PMID: 15227559, DOI: 10.1055/s-0038-1633870.Peer-Reviewed Original ResearchConceptsDatabase applicationsClinical study data management systemsIntegration of applicationsCommon semantic modelData management systemWeb-based repositoryClinical research databaseSchema conflictsSharing of featuresData managementMapping schemaSemantic modelDifferent operating environmentsModel unificationManagement systemIntegration effortsOperating environmentArea of applicabilityData collectionMajor benefitsSimilar purposesIntegrationApplicationsCritical conflictsData libraries
2000
Using a Computer Database to Monitor Compliance With Pharmacotherapeutic Guidelines for Schizophrenia
Chen RS, Nadkarni PM, Levin FL, Miller PL, Erdos J, Rosenheck RA. Using a Computer Database to Monitor Compliance With Pharmacotherapeutic Guidelines for Schizophrenia. Psychiatric Services 2000, 51: 791-794. PMID: 10828112, DOI: 10.1176/appi.ps.51.6.791.Peer-Reviewed Original ResearchConceptsPatient Outcomes Research TeamAcute episodePrescription dataSchizophrenia Patient Outcomes Research TeamVeterans Affairs Medical CenterTrial of clozapinePercent of patientsFirst-line treatmentPatient prescription dataPharmacotherapeutic guidelinesPharmacotherapeutic recommendationsAdequate trialConventional antipsychoticsConventional medicationsConventional regimensOutpatient visitsAntipsychotic regimenTreatment recommendationsSymptom episodesMedical CenterPatientsClozapineConventional drugsComputerized databasePORT recommendations