2009
Automated Database Mediation Using Ontological Metadata Mappings
Marenco L, Wang R, Nadkarni P. Automated Database Mediation Using Ontological Metadata Mappings. Journal Of The American Medical Informatics Association 2009, 16: 723-737. PMID: 19567801, PMCID: PMC2744723, DOI: 10.1197/jamia.m3031.Peer-Reviewed Original ResearchConceptsCross-database queriesHigh-level rulesEnforcement of constraintsDatabase MediationDatabase federationsDatabase ontologyExtended metadataGranularity levelsMetadata mappingBiomedical ontologiesDifferent granularitiesFramework simplifiesCategories of dataMaintenance of systemsMapping rulesQueriesDatabase informationGranularity of representationGlobal vocabularyOntologyGranularityIntegrator systemMetadataDatabaseSNOMED
2004
QIS: A Framework for Biomedical Database Federation
Marenco L, Wang TY, Shepherd G, Miller PL, Nadkarni P. QIS: A Framework for Biomedical Database Federation. Journal Of The American Medical Informatics Association 2004, 11: 523-534. PMID: 15298995, PMCID: PMC524633, DOI: 10.1197/jamia.m1506.Peer-Reviewed Original ResearchConceptsNetwork-based serversHeterogeneous data sourcesRobust data integrationIntegration serverOntology serverDatabase federationsSource serverNeuroscience databasesData integrationMediator frameworkServerData elementsQueriesData sourcesMetadataPrototype stageStandard technologyIntegrator systemGenomic databasesFrameworkDatabaseOntologyArchitectureSchemaTechnological expertise
2003
Achieving Evolvable Web-Database Bioscience Applications Using the EAV/CR Framework: Recent Advances
Marenco L, Tosches N, Crasto C, Shepherd G, Miller PL, Nadkarni PM. Achieving Evolvable Web-Database Bioscience Applications Using the EAV/CR Framework: Recent Advances. Journal Of The American Medical Informatics Association 2003, 10: 444-453. PMID: 12807806, PMCID: PMC212781, DOI: 10.1197/jamia.m1303.Peer-Reviewed Original ResearchMeSH KeywordsDatabase Management SystemsDatabases as TopicInternetProgramming LanguagesSemanticsSoftwareVocabulary, ControlledConceptsEAV/CRXML-based protocolHuman Brain ProjectDatabase supportData querySemantic descriptorsAutomatic generationNeuroscience databasesCR frameworkScientific domainsBrain ProjectInterclass relationshipsSchema maintenanceFrameworkBioscience applicationsResearch focusQueriesMetadataDatabaseUMLSUsersData extractionDifferent subsetsSchemaParticular research focusText mining neuroscience journal articles to populate neuroscience databases
Crasto CJ, Marenco LN, Migliore M, Mao B, Nadkarni PM, Miller P, Shepherd GM. Text mining neuroscience journal articles to populate neuroscience databases. Neuroinformatics 2003, 1: 215-237. PMID: 15046245, DOI: 10.1385/ni:1:3:215.Peer-Reviewed Original ResearchConceptsNeuroscience databasesNatural language textPre-processing stepDatabase architectureLanguage textRetrieval resultsDatabase keywordsSemantic contextBibliography databasesNeuroscience articlesTest setTwo-step approachFirst stepDatabaseExpertsArchitectureSoftwareKnowledgebaseSecond stepNeuroscienceSenseLabKeywordsContinual improvementStepAccuracyCreating knowledgebases to text-mine PUBMED articles using clustering techniques.
Crasto CJ, Morse TM, Migliore M, Nadkarni P, Hines M, Brash DE, Miller PL, Shepherd GM. Creating knowledgebases to text-mine PUBMED articles using clustering techniques. AMIA Annual Symposium Proceedings 2003, 2003: 821. PMID: 14728326, PMCID: PMC1479923.Peer-Reviewed Original Research
2002
Metadata-driven creation of data marts from an EAV-modeled clinical research database
Brandt CA, Morse R, Matthews K, Sun K, Deshpande AM, Gadagkar R, Cohen DB, Miller PL, Nadkarni PM. Metadata-driven creation of data marts from an EAV-modeled clinical research database. International Journal Of Medical Informatics 2002, 65: 225-241. PMID: 12414020, DOI: 10.1016/s1386-5056(02)00047-3.Peer-Reviewed Original ResearchConceptsData martClinical study data management systemsTransaction-oriented systemsData management systemClinical research databaseDatabase schemaEntity attributesAnalytical processingHuman interpretationStudy metadataMetadataManagement systemArbitrary numberData entrySuch dataBrowsingValue modelSchemaMartHigher-level groupingsSystemDataProcessingDatabaseCreation
2001
Easing the transition between attribute-value databases and conventional databases for scientific data.
Nadkarni P, Marenco L. Easing the transition between attribute-value databases and conventional databases for scientific data. AMIA Annual Symposium Proceedings 2001, 483-7. PMID: 11825235, PMCID: PMC2243470.Peer-Reviewed Original ResearchMeSH KeywordsDatabase Management SystemsDatabases as TopicSystems IntegrationUser-Computer InterfaceConceptsEAV/CRData transfer toolsData transfer programProgrammer interventionConventional databasesLegacy systemsDB technologyDevelopment frameworkGeneric toolData sourcesDifferent representationsConventional dataAnalytical packageDatabaseScientific dataTransfer toolsScientific databasesTransfer taskToolProgrammingTaskCurrent limitationsWide varietyTechnologyFramework
2000
Reengineering a Database for Clinical Trials Management Lessons for System Architects
Brandt C, Nadkarni P, Marenco L, Karras B, Lu C, Schacter L, Fisk J, Miller P. Reengineering a Database for Clinical Trials Management Lessons for System Architects. Contemporary Clinical Trials 2000, 21: 440-461. PMID: 11018562, DOI: 10.1016/s0197-2456(00)00070-2.Peer-Reviewed Original ResearchExploring Performance Issues for a Clinical Database Organized Using an Entity-Attribute-Value Representation
Chen R, Nadkarni P, Marenco L, Levin F, Erdos J, Miller P. Exploring Performance Issues for a Clinical Database Organized Using an Entity-Attribute-Value Representation. Journal Of The American Medical Informatics Association 2000, 7: 475-487. PMID: 10984467, PMCID: PMC79043, DOI: 10.1136/jamia.2000.0070475.Peer-Reviewed Original ResearchMeSH KeywordsDatabase Management SystemsDatabases as TopicDatabases, FactualInformation Storage and RetrievalMicrobiologyPilot ProjectsConceptsEAV/CRDatabase schemaSQL statementsDatabase modelDatabase sizeSystem memoryQuery execution timeHeterogeneous biomedical dataSimple SQL statementsQuery efficiencyQuery performancePowerful hardwareQuery strategyEntity attributesDatabase queriesDatabase representationBiomedical dataExecution timeQueriesMore memoryPerformance issuesSchemaValue representationRepresentationCR modelWebEAV
Nadkarni P, Brandt C, Marenco L. WebEAV. Journal Of The American Medical Informatics Association 2000, 7: 343-356. PMID: 10887163, PMCID: PMC61439, DOI: 10.1136/jamia.2000.0070343.Peer-Reviewed Original ResearchConceptsWeb development environmentWeb application developmentUser interface issuesClient-server technologyValue databaseWeb technologiesApplication developmentEntity attributesWeb developmentDevelopment environmentWeb interfaceGeneric frameworkInterface issuesComplex systemsFront endDatabaseTechnologyMetadataDevelopersSuitable examplesArchitectureTaskFeaturesFrameworkVehiclesUsing a Computer Database to Monitor Compliance With Pharmacotherapeutic Guidelines for Schizophrenia
Chen RS, Nadkarni PM, Levin FL, Miller PL, Erdos J, Rosenheck RA. Using a Computer Database to Monitor Compliance With Pharmacotherapeutic Guidelines for Schizophrenia. Psychiatric Services 2000, 51: 791-794. PMID: 10828112, DOI: 10.1176/appi.ps.51.6.791.Peer-Reviewed Original ResearchConceptsPatient Outcomes Research TeamAcute episodePrescription dataSchizophrenia Patient Outcomes Research TeamVeterans Affairs Medical CenterTrial of clozapinePercent of patientsFirst-line treatmentPatient prescription dataPharmacotherapeutic guidelinesPharmacotherapeutic recommendationsAdequate trialConventional antipsychoticsConventional medicationsConventional regimensOutpatient visitsAntipsychotic regimenTreatment recommendationsSymptom episodesMedical CenterPatientsClozapineConventional drugsComputerized databasePORT recommendations
1999
Organization of Heterogeneous Scientific Data Using the EAV/CR Representation
Nadkarni P, Marenco L, Chen R, Skoufos E, Shepherd G, Miller P. Organization of Heterogeneous Scientific Data Using the EAV/CR Representation. Journal Of The American Medical Informatics Association 1999, 6: 478-493. PMID: 10579606, PMCID: PMC61391, DOI: 10.1136/jamia.1999.0060478.Peer-Reviewed Original ResearchMeSH KeywordsDatabase Management SystemsDatabases as TopicHumansInternetMEDLINENervous SystemSemanticsSmellConceptsEAV/CRHeterogeneous scientific dataPhysical database schemaStorage of dataInterobject relationshipsDatabase schemaHeterogeneous dataMedical domainComplex objectsScientific domainsClinical patient recordsSchemaBiomedical databasesRepresentationScientific dataPatient recordsSuch purposesDatabaseValue representationDomainObjectsParadigmData
1998
Automatic query mapping among genomic databases: a pilot exploration.
Cheung KH, Nadkarni P, Miller P, Shin DG. Automatic query mapping among genomic databases: a pilot exploration. AMIA Annual Symposium Proceedings 1998, 942-6. PMID: 9929357, PMCID: PMC2232293.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsDatabases as TopicDatabases, FactualGenome, HumanHuman Genome ProjectHumansInformation Storage and RetrievalMethodsPilot Projects