2024
Disentangling the influence of reservoir abundance and pathogen shedding on zoonotic spillover of the Leptospira agent in urban informal settlements
Soni N, Eyre M, Souza F, Diggle P, Ko A, Begon M, Pickup R, Childs J, Khalil H, Carvalho-Pereira T, Pertile A, Carvalho M, de Oliveira D, Nery N, Giorgi E, Costa F. Disentangling the influence of reservoir abundance and pathogen shedding on zoonotic spillover of the Leptospira agent in urban informal settlements. Frontiers In Public Health 2024, 12: 1447592. PMID: 39360250, PMCID: PMC11445007, DOI: 10.3389/fpubh.2024.1447592.Peer-Reviewed Original ResearchRat abundanceReservoir abundanceAbundance of ratsEnvironmentally transmitted diseasesVegetation land coverInfection riskSexually mature ratsHuman infection riskLive trapsUrban informal settlementsZoonotic spilloverLand coverSpatial variationHydrological factorsValley bottomTrack plateAbundanceHuman riskShedding rateMature ratsEco-epidemiological studiesLeptospira infectionSpillover transmissionSpatial distributionInformal settlementsFactors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil
de Oliveira D, Khalil H, Palma F, Santana R, Nery N, Quintero-Vélez J, Zeppelini C, do Sacramento G, Cruz J, Lustosa R, Ferreira I, Carvalho-Pereira T, Diggle P, Wunder E, Ko A, Lopez Y, Begon M, Reis M, Costa F. Factors associated with differential seropositivity to Leptospira interrogans and Leptospira kirschneri in a high transmission urban setting for leptospirosis in Brazil. PLOS Neglected Tropical Diseases 2024, 18: e0011292. PMID: 38758957, PMCID: PMC11139309, DOI: 10.1371/journal.pntd.0011292.Peer-Reviewed Original ResearchYears of ageResidents of low-income areasMultinomial logistic regression modelWork-related exposureEpidemiological patternsLow-income areasLogistic regression modelsInformal urban communitiesFactors associated with seropositivityCity of SalvadorPathogenic species of bacteriaUrban settingsUrban communitiesLongitudinal Data Analysis
Diggle P, Taylor-Robinson D. Longitudinal Data Analysis. 2024, 1-34. DOI: 10.1007/978-1-4614-6625-3_75-1.Peer-Reviewed Original ResearchTime-to-event outcomesBinary responsesTreatment of missing valuesClinical trials of drug therapyJoint modelTrials of drug therapyCystic fibrosis patientsLongitudinal studyLinear modelCross-sectional studySchizophrenia patientsFibrosis patientsLong-term progressionDrug therapyClinical trialsLung functionObservational studyNon-independencePatientsOutcome variablesStatistical methodsHow Does the Proportion of Never Treatment Influence the Success of Mass Drug Administration Programs for the Elimination of Lymphatic Filariasis?
Kura K, Stolk W, Basáñez M, Collyer B, de Vlas S, Diggle P, Gass K, Graham M, Hollingsworth T, King J, Krentel A, Anderson R, Coffeng L. How Does the Proportion of Never Treatment Influence the Success of Mass Drug Administration Programs for the Elimination of Lymphatic Filariasis? Clinical Infectious Diseases 2024, 78: s93-s100. PMID: 38662701, PMCID: PMC11045024, DOI: 10.1093/cid/ciae021.Peer-Reviewed Original ResearchConceptsMass drug administrationElimination of lymphatic filariasisEfficacious treatment regimensLymphatic filariasisLevels of NTMass drug administration programmesYears of annual treatmentTreatment regimensDrug combinationsTransmission settingsMass drug administration programsDrug AdministrationTreatment coveragePrevalenceTransmission areasMDA coverageBaselineProportion of peopleTreatmentPrevalence thresholdImpact of NTAlbendazoleDiethylcarbamazineHighest infection prevalenceHighest proportionA Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design
Eyre M, Bulstra C, Johnson O, de Vlas S, Diggle P, Fronterrè C, Coffeng L. A Comparison of Markov and Mechanistic Models for Soil-Transmitted Helminth Prevalence Projections in the Context of Survey Design. Clinical Infectious Diseases 2024, 78: s146-s152. PMID: 38662703, PMCID: PMC11045013, DOI: 10.1093/cid/ciae022.Peer-Reviewed Original ResearchConceptsOptimal survey designImpact assessment surveysSurvey designProjected prevalenceGeostatistical methodsPrevalence surveySampling designSchool-aged childrenPreventive chemotherapySoil-transmitted helminthsPrevalence projectionsControl programsWorld Health OrganizationAssessment surveyPrevalence dataSub-Saharan AfricaMechanistic modelTarget of PCSoutheast AsiaHealth OrganizationMechanistic methodsPrevalenceBillion peopleSub-SaharanInadequate sanitationImproving the Cost-efficiency of Preventive Chemotherapy: Impact of New Diagnostics on Stopping Decisions for Control of Schistosomiasis
Coffeng L, Graham M, Browning R, Kura K, Diggle P, Denwood M, Medley G, Anderson R, de Vlas S. Improving the Cost-efficiency of Preventive Chemotherapy: Impact of New Diagnostics on Stopping Decisions for Control of Schistosomiasis. Clinical Infectious Diseases 2024, 78: s153-s159. PMID: 38662699, PMCID: PMC11045014, DOI: 10.1093/cid/ciae020.Peer-Reviewed Original ResearchIntegrating wastewater and randomised prevalence survey data for national COVID surveillance
Li G, Diggle P, Blangiardo M. Integrating wastewater and randomised prevalence survey data for national COVID surveillance. Scientific Reports 2024, 14: 5124. PMID: 38429366, PMCID: PMC10907376, DOI: 10.1038/s41598-024-55752-9.Peer-Reviewed Original ResearchConceptsPrevalence dataPrevalence surveySurveillance systemCollection of health dataDisease prevalenceMeasures of prevalenceLocal disease prevalenceWastewaterSpatial resolutionWastewater dataPrevalence survey dataHealth dataReduced scaleDisease metricsCoarser spatial resolutionDisease-agnosticPrevalenceCOVID-19 pandemicSurveillance toolPost-pandemic settingEarly detectionNon-epidemic periodsCost-effective mannerSurveyDetect outbreaksAudio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers
Coppock H, Nicholson G, Kiskin I, Koutra V, Baker K, Budd J, Payne R, Karoune E, Hurley D, Titcomb A, Egglestone S, Tendero Cañadas A, Butler L, Jersakova R, Mellor J, Patel S, Thornley T, Diggle P, Richardson S, Packham J, Schuller B, Pigoli D, Gilmour S, Roberts S, Holmes C. Audio-based AI classifiers show no evidence of improved COVID-19 screening over simple symptoms checkers. Nature Machine Intelligence 2024, 6: 229-242. DOI: 10.1038/s42256-023-00773-8.Peer-Reviewed Original Research
2023
Basic urban services fail to neutralise environmental determinants of ‘rattiness’, a composite metric of rat abundance
Carvalho-Pereira T, Eyre M, Zeppelini C, Espirito Santo V, Santiago D, Santana R, Palma F, Reis M, Lustosa R, Khalil H, Diggle P, Giorgi E, Costa F, Begon M. Basic urban services fail to neutralise environmental determinants of ‘rattiness’, a composite metric of rat abundance. Urban Ecosystems 2023, 27: 757-771. DOI: 10.1007/s11252-023-01481-2.Peer-Reviewed Original ResearchWastewater-based surveillance models for COVID-19: A focused review on spatio-temporal models
Torabi F, Li G, Mole C, Nicholson G, Rowlingson B, Smith C, Jersakova R, Diggle P, Blangiardo M. Wastewater-based surveillance models for COVID-19: A focused review on spatio-temporal models. Heliyon 2023, 9: e21734. PMID: 38053867, PMCID: PMC10694161, DOI: 10.1016/j.heliyon.2023.e21734.Peer-Reviewed Original ResearchUsing a model-based geostatistical approach to design and analyse the prevalence of schistosomiasis in Kenya
Okoyo C, Minnery M, Orowe I, Owaga C, Wambugu C, Olick N, Hagemann J, Omondi W, Gichuki P, McCracken K, Montresor A, Fronterre C, Diggle P, Mwandawiro C. Using a model-based geostatistical approach to design and analyse the prevalence of schistosomiasis in Kenya. Frontiers In Tropical Diseases 2023, 4: 1240617. DOI: 10.3389/fitd.2023.1240617.Peer-Reviewed Original ResearchTreatment strategy changesSchool-based deworming programmePublic health problemPrevalence of schistosomiasisWorld Health Organization guidelinesCross-sectional surveyHealth Organization guidelinesPredictive probabilitySCH prevalenceDeworming programsSchistosoma haematobiumHealth problemsSchistosoma mansoniOrganization guidelinesStudy designCounties of KenyaPrevalenceSchistosomiasisHighest predictive probabilityParasitic wormsTreatment requirementsTreatmentGuidelinesMorbidityHaematobium
2013
WS11.5 The effect of social deprivation, disease severity, and time in hospital on employment chances in the UK cystic fibrosis population: A longitudinal study
Taylor-Robinson D, Smyth R, Diggle P, Whitehead M. WS11.5 The effect of social deprivation, disease severity, and time in hospital on employment chances in the UK cystic fibrosis population: A longitudinal study. Journal Of Cystic Fibrosis 2013, 12: s23. DOI: 10.1016/s1569-1993(13)60068-5.Peer-Reviewed Original Research
2012
137 The effect of social deprivation on Pseudomonas and staphylococcal colonisation in the UK cystic fibrosis population
Taylor-Robinson D, Whitehead M, Diggle P, Smyth R. 137 The effect of social deprivation on Pseudomonas and staphylococcal colonisation in the UK cystic fibrosis population. Journal Of Cystic Fibrosis 2012, 11: s91. DOI: 10.1016/s1569-1993(12)60307-5.Peer-Reviewed Original ResearchWS3.3 Longitudinal changes in lung function and risk of death in cystic fibrosis: developing a joint model for the UK population
Taylor-Robinson D, Whitehead M, Smyth R, Diggle P, Henderson R, Barrett J. WS3.3 Longitudinal changes in lung function and risk of death in cystic fibrosis: developing a joint model for the UK population. Journal Of Cystic Fibrosis 2012, 11: s6. DOI: 10.1016/s1569-1993(12)60021-6.Peer-Reviewed Original Research
2011
SP1-53 The effect of social deprivation on weight in the UK cystic fibrosis population
Taylor-Robinson D, Whitehead M, Diggle P, Smyth R. SP1-53 The effect of social deprivation on weight in the UK cystic fibrosis population. Journal Of Epidemiology & Community Health 2011, 65: a389-a389. DOI: 10.1136/jech.2011.142976n.30.Peer-Reviewed Original Research282 The effect of social deprivation on weight in the UK cystic fibrosis population
Taylor-Robinson D, Whitehead M, Diggle P, Smyth R. 282 The effect of social deprivation on weight in the UK cystic fibrosis population. Journal Of Cystic Fibrosis 2011, 10: s72. DOI: 10.1016/s1569-1993(11)60296-8.Peer-Reviewed Original Research