2023
Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations
Krishnan M, Phipps-Green A, Russell E, Major T, Cadzow M, Stamp L, Dalbeth N, Hindmarsh J, Qasim M, Watson H, Liu S, Carlson J, Minster R, Hawley N, Naseri T, Reupena M, Deka R, McGarvey S, Merriman T, Murphy R, Weeks D. Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations. Journal Of Human Genetics 2023, 68: 463-468. PMID: 36864286, PMCID: PMC10313811, DOI: 10.1038/s10038-023-01141-5.Peer-Reviewed Original ResearchConceptsBody mass indexMean body mass indexHigher body mass indexPrevious smaller studiesAssociation of rs9939609New Zealand PolynesiansMass indexFat massSmall studySignificant associationPolynesian ancestryFTO variantsRs9939609Effect size estimatesAssociationSimilar effectsMean effect size estimate
2022
CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesAssociation of BMIHigher body mass indexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals