2023
Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics
Hollingsworth B, Grubaugh N, Lazzaro B, Murdock C. Leveraging insect-specific viruses to elucidate mosquito population structure and dynamics. PLOS Pathogens 2023, 19: e1011588. PMID: 37651317, PMCID: PMC10470969, DOI: 10.1371/journal.ppat.1011588.Peer-Reviewed Original ResearchConceptsInsect-specific virusesPopulation structureMosquito viromeFine-scale genetic variationMosquito ecologyDiversity of virusesMosquito population structureMovement ratesMultiple spatial scalesViral ecologyGenetic variationHost genomeDisease ecologyCryptic aspectsVirome studiesEcologyViral discoveryViral phylogenyMosquito control programsViromeGenomeGenomic epidemiologySpatial scalesPhylogenyRelevant timescales
2021
Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses
Mytle N, Leyrer S, Inglefield JR, Harris AM, Hickey TE, Minang J, Lu H, Ma Z, Andersen H, Grubaugh ND, Guina T, Skiadopoulos MH, Lacy MJ. Influenza Antigens NP and M2 Confer Cross Protection to BALB/c Mice against Lethal Challenge with H1N1, Pandemic H1N1 or H5N1 Influenza A Viruses. Viruses 2021, 13: 1708. PMID: 34578289, PMCID: PMC8473317, DOI: 10.3390/v13091708.Peer-Reviewed Original ResearchConceptsBALB/c miceC miceAntigens of influenzaSeasonal influenza vaccineInfluenza virus antigensSerum antibody responseVaccinia virus AnkaraMajor protective antigenMatrix protein 2Influenza A virusesViral burdenInfluenza vaccineAnnual immunizationProtective immunityLethal challengeAntibody responseVirus antigenVirus AnkaraNatural immunityAntigen hemagglutininM2e antigenAntigenic driftA virusAntigenProtective antigen