Transmission bottlenecks and RNAi collectively influence tick-borne flavivirus evolution
Grubaugh ND, Rückert C, Armstrong PM, Bransfield A, Anderson JF, Ebel GD, Brackney DE. Transmission bottlenecks and RNAi collectively influence tick-borne flavivirus evolution. Virus Evolution 2016, 2: vew033. PMID: 28058113, PMCID: PMC5210029, DOI: 10.1093/ve/vew033.Peer-Reviewed Original ResearchSimilar selective pressuresMicro-evolutionary forcesGreat genetic plasticityArthropod-borne RNA virusesVirus populationsLong-term evolutionary trendsGenetic bottleneckSelective constraintsFlavivirus evolutionEcological nichesGenetic plasticitySelective pressureVertebrate hostsPopulation dynamicsArthropod-borne virusesRNA virusesEvolutionary trendsArthropod vectorsMolecular levelMechanistic explanationTransmission bottleneckHostHeterogeneous populationUnique rateRNAi