2019
Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging
Beam CR, Turkheimer E, Finkel D, Levine ME, Zandi E, Guterbock TM, Giangrande EJ, Ryan L, Pasquenza N, Davis DW. Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging. Behavior Genetics 2019, 50: 73-83. PMID: 31820295, PMCID: PMC7033012, DOI: 10.1007/s10519-019-09983-6.Peer-Reviewed Original ResearchConceptsLouisville Twin StudyCognitive developmentCognitive agingCognitive functioningCognitive developmental trajectoriesLongitudinal Twin StudyTwin studiesPhysical health factorsEpisodic memoryLower biological ageFunctional ability measuresIQ measuresAbility measuresDevelopmental trajectoriesFSIQ scoresMidlife phaseMidlife studyPhysical functioningFunctional abilityChronological ageFunctioningPsychiatric outcomesSecond pilot studySecond studyIQ
2015
Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning
Levine ME, Lu AT, Bennett DA, Horvath S. Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning. Aging 2015, 7: 1198-1211. PMID: 26684672, PMCID: PMC4712342, DOI: 10.18632/aging.100864.Peer-Reviewed Original ResearchConceptsCognitive functioningBrain ageCognitive declineGlobal cognitive functioningAccurate epigenetic biomarkerPre-frontal cortexEpisodic memoryAge related neurodegenerationReligious Orders StudyRush MemoryMemoryAging ProjectAlzheimer's diseaseNeuropathological measurementsNeuropathological markersFunctioningRelated neurodegenerationDorsolateral prefrontal cortex samplesOrders StudyEpigenetic age accelerationComplex trait analysisDLPFCSignificant genetic correlationsAge accelerationAmyloid load
2012
Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation?
Levine ME, Crimmins EM. Sarcopenic Obesity and Cognitive Functioning: The Mediating Roles of Insulin Resistance and Inflammation? Current Gerontology And Geriatrics Research 2012, 2012: 826398. PMID: 22611388, PMCID: PMC3352243, DOI: 10.1155/2012/826398.Peer-Reviewed Original ResearchInsulin resistanceBody compositionAdults age 60Muscle massAge 60Non-obese older adultsCognitive functioningCognitive performanceOlder adultsSarcopenic nonobeseSarcopenic obeseHigh CRPSarcopenic obesityWorse cognitive functioningWaist circumferenceMultiple physiological systemsNHANES 1999Abdominal fatObesityMetabolic deregulationLower cognitionAdultsObeseSarcopeniaInflammation