2012
Soluble Vascular Cell Adhesion Molecule Levels, Endothelin-1 and Endothelial Nitric Oxide Synthase Gene Polymorphisms: Association with Clinical Symptoms in Sickle Cell Anemia.
Vilas-Boas W, Figueiredo C, Cerqueira B, Pitanga T, Zanette A, Reis M, Goncalves M. Soluble Vascular Cell Adhesion Molecule Levels, Endothelin-1 and Endothelial Nitric Oxide Synthase Gene Polymorphisms: Association with Clinical Symptoms in Sickle Cell Anemia. Blood 2012, 120: 2118. DOI: 10.1182/blood.v120.21.2118.2118.Peer-Reviewed Original ResearchAcute chest syndromeT gene polymorphismEndothelial nitric oxide synthaseSoluble adhesion moleculesAdhesion molecule-1Endothelin-1HbSS patientsENOS -786TGene polymorphismsMedical historyMolecule-1Vascular cell adhesion molecule levelsEndothelial nitric oxide synthase gene polymorphismsSoluble intercellular adhesion molecule-1Nitric oxide synthase gene polymorphismsC gene promoter polymorphismsCell adhesion molecule levelsNitric oxide synthesis pathwayVascular cell adhesion molecule-1Intercellular adhesion molecule-1Adhesion moleculesCell adhesion molecule-1Levels of sICAMAdhesion molecule levelsIncreased inflammatory state
2011
TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia
Cajado C, Cerqueira B, Couto F, Moura-Neto J, Vilas-Boas W, Dorea M, Lyra I, Barbosa C, Reis M, Goncalves M. TNF-alpha and IL-8: Serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 2011, 56: 312-317. PMID: 21802960, DOI: 10.1016/j.cyto.2011.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesAnemia, Sickle CellBiomarkersCase-Control StudiesChildChild, PreschoolCross-Sectional StudiesEnzyme-Linked Immunosorbent AssayHaplotypesHumansInterleukin-8Medical History TakingPolymerase Chain ReactionPolymorphism, GeneticPolymorphism, Restriction Fragment LengthTumor Necrosis Factor-alphaConceptsSickle cell anemiaTNF-alpha -308GT gene polymorphismGene polymorphismsIL-8Serum levelsMedical historyTNF-alphaCell anemiaHigher TNF-alpha levelsIL-8 gene polymorphismsA alleleClassical biomarkersSteady-state sickle cell anemiaTNF-alpha levelsHeterogeneous clinical outcomesLogistic regression analysisYears of ageCytokine levelsClinical outcomesImmunological biomarkersHealthy controlsPatient outcomesInterleukin-8SCA patients
2008
Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Souza C, Barbosa C, de Moura Neto J, Barreto J, Reis M, Gonçalves M. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics And Molecular Biology 2008, 31: 39-41. DOI: 10.1590/s1415-47572008000100008.Peer-Reviewed Original ResearchChronic myeloid leukemiaAcute promyelocytic leukemiaRisk factorsMyeloid leukemiaTypes of leukemiaGlutathione S-transferase thetaGSTT1null genotypeAPL patientsGSTM1 polymorphismHealthy controlsBrazilian patientsPromyelocytic leukemiaNull genotypeControl groupGene polymorphismsGSTT1 genesLeukemiaPatientsMultiplex PCRPolymorphismDifferent populationsAssociation studiesGroup