2006
Hormonal Regulation of Nuclear Permeability* ♦
O'Brien EM, Gomes DA, Sehgal S, Nathanson MH. Hormonal Regulation of Nuclear Permeability* ♦. Journal Of Biological Chemistry 2006, 282: 4210-4217. PMID: 17158097, PMCID: PMC2835336, DOI: 10.1074/jbc.m606300200.Peer-Reviewed Original ResearchConceptsProtein kinase CNuclear permeabilityGene transcriptionNuclear envelopeSecond messengerKinase CPhotoactivatable green fluorescent proteinCertain G protein-coupled receptorsG protein-coupled receptorsActivate protein kinase CCytosolic Ca2Protein-coupled receptorsGreen fluorescent proteinTargeting sequenceTranscription factorsRegulatory moleculesNuclear membraneFluorescent proteinPassage of moleculesIntranuclear eventsNovel mechanismShort-term regulationHormonal regulationTranscriptionRegulation
2003
Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum
Echevarría W, Leite MF, Guerra MT, Zipfel WR, Nathanson MH. Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nature Cell Biology 2003, 5: 440-446. PMID: 12717445, PMCID: PMC3572851, DOI: 10.1038/ncb980.Peer-Reviewed Original ResearchMeSH KeywordsActive Transport, Cell NucleusCalciumCalcium ChannelsCalcium SignalingCell MembraneCell Nucleus StructuresCytosolEndoplasmic ReticulumEukaryotic CellsHumansInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsMicroscopy, ConfocalNuclear EnvelopePhotochemistryProtein Kinase CProtein TransportReceptors, Cytoplasmic and NuclearTumor Cells, CulturedConceptsProtein kinase CNucleoplasmic reticulumCalcium signalsNuclear envelopeNuclear protein kinase CNuclear calcium signalsCytosolic protein kinase CGene transcriptionInduces translocationNuclear calcium storesPlasma membraneCytosolic calcium signalsSubnuclear regionsEndoplasmic reticulumSecond messengerKinase CTrisphosphate receptorCell growthReticulumNuclear componentsReticular networkPotential mechanismsCalcium storesRelease of calciumNucleusNuclear and cytosolic calcium are regulated independently
Leite MF, Thrower EC, Echevarria W, Koulen P, Hirata K, Bennett AM, Ehrlich BE, Nathanson MH. Nuclear and cytosolic calcium are regulated independently. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 2975-2980. PMID: 12606721, PMCID: PMC151451, DOI: 10.1073/pnas.0536590100.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateCalciumCalcium ChannelsCell LineCell MembraneCell NucleusCytosolDose-Response Relationship, DrugEndoplasmic ReticulumHumansImmunoblottingImmunohistochemistryInositol 1,4,5-Trisphosphate ReceptorsLipid BilayersMicroscopy, ConfocalProtein IsoformsReceptors, Cytoplasmic and NuclearSignal TransductionTime FactorsConceptsEndoplasmic reticulumImportant cellular processesType II isoformCellular processesCellular compartmentsGene transcriptionEnriched expressionNuclear calciumTrisphosphate receptorIndependent regulationCytosolLiver cell lineCell linesHepG2 liver cell lineSubcellular mechanismsReticulumNucleus resultsDependent processesCytosolic calciumNucleusTranscriptionType ISignalingIsoformsSimilar extent