2022
Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens
Sakyi SA, Wilson MD, Adu B, Opoku S, Brewoo A, Larbi A, Baafour EK, Tchum SK, Saahene RO, Aniagyei W, Sewor C, Courtin D, Cappello M, Gyan B, Amoani B. Plasmodium falciparum coinfection is associated with improved IgE and IgG3 response against hookworm antigens. Health Science Reports 2022, 5: e672. PMID: 35734341, PMCID: PMC9195015, DOI: 10.1002/hsr2.672.Peer-Reviewed Original ResearchL3 stage larvaeAlbendazole treatmentHookworm infectionImmune responseNonendemic controlsPlasmodium falciparum coinfectionsIron deficiency anemiaHookworm treatmentVaccine effectivenessIgG3 responsesIgG responsesAntibody profileSingle doseDeficiency anemiaIgG3 antibodiesBlood samplesIgEProtein malnutritionControl groupVaccine developmentHigh levelsSerum samplesIgG3Stage larvaeInfection
2013
Ancylostoma ceylanicum metalloprotease 6 DNA vaccination induces partial protection against hookworm challenge infection
Wiśniewski M, Jaros S, Bąska P, Cappello M, Wędrychowicz H. Ancylostoma ceylanicum metalloprotease 6 DNA vaccination induces partial protection against hookworm challenge infection. Acta Parasitologica 2013, 58: 376-383. PMID: 23990436, DOI: 10.2478/s11686-013-0151-9.Peer-Reviewed Original ResearchConceptsChallenge infectionAnthelminthic drug resistanceEffective human vaccineWorm burden reductionsGroups of hamstersIron deficiency anemiaCDNA vaccineTriple immunizationInfected childrenDeficiency anemiaDNA vaccineHookworm infectionDNA vaccinationHuman vaccinesAnimal modelsNumerous antigensVaccine developmentGrowth retardationIntestinal nematodesDrug resistanceVaccineBurden reductionPartial protectionInfectionHemoglobin digestion
2012
Frequency and intensity of exposure mediate resistance to experimental infection with the hookworm, Ancylostoma ceylanicum
Davey D, Manickam N, Simms BT, Harrison LM, Vermeire JJ, Cappello M. Frequency and intensity of exposure mediate resistance to experimental infection with the hookworm, Ancylostoma ceylanicum. Experimental Parasitology 2012, 133: 243-249. PMID: 23232252, PMCID: PMC3580025, DOI: 10.1016/j.exppara.2012.11.010.Peer-Reviewed Original ResearchConceptsExperimental infectionThird-stage hookworm larvaeParasite-specific IgAHumoral immune responseStudy of pathogenesisResource-limited countriesHuman hookworm diseaseHookworm infectionLifelong susceptibilityPrimary infectionImmune responseProlonged susceptibilitySubsequent challengeAntibody productionVaccine developmentHookworm larvaeHookworm diseaseIntestinal nematodesInfectionPathological effectsRepeated exposureAncylostoma ceylanicumContinued susceptibilityMajor causeMediate resistance
2009
Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum
Fairfax KC, Vermeire JJ, Harrison LM, Bungiro RD, Grant W, Husain SZ, Cappello M. Characterisation of a fatty acid and retinol binding protein orthologue from the hookworm Ancylostoma ceylanicum. International Journal For Parasitology 2009, 39: 1561-1571. PMID: 19591834, PMCID: PMC2760681, DOI: 10.1016/j.ijpara.2009.06.005.Peer-Reviewed Original ResearchConceptsMucosal adjuvant cholera toxinAdjuvant cholera toxinCause of anemiaLive adult wormsIntestinal worm burdenFatty acidsResource limited countriesFatty acid uptakeHookworm Ancylostoma ceylanicumReal-time PCRFatty acids de novoWorm burdenVaccine developmentLimited countriesIntestinal nematodesEx vivoA. ceylanicumCholera toxinHookworm biologyIndividual fatty acidsAncylostoma ceylanicumAcid uptakeAdult wormsProtein 1Potential role
2001
Molecular Characterization of Ancylostoma Inhibitors of Coagulation Factor Xa HOOKWORM ANTICOAGULANT ACTIVITY IN VITRO PREDICTS PARASITE BLOODFEEDING IN VIVO *
Harrison LM, Nerlinger A, Bungiro RD, Córdova JL, Kuzmič P, Cappello M. Molecular Characterization of Ancylostoma Inhibitors of Coagulation Factor Xa HOOKWORM ANTICOAGULANT ACTIVITY IN VITRO PREDICTS PARASITE BLOODFEEDING IN VIVO *. Journal Of Biological Chemistry 2001, 277: 6223-6229. PMID: 11741914, DOI: 10.1074/jbc.m109908200.Peer-Reviewed Original ResearchConceptsCoagulation factor XaAdult A. ceylanicumHookworm speciesHuman vaccine developmentIron deficiency anemiaAnticoagulant activityFactor Xa inhibitory activityFactor Xa activityDog hookworm Ancylostoma caninumFactor XaXa inhibitory activityMechanism of actionFirst anticoagulantGastrointestinal hemorrhageDeficiency anemiaReverse transcription-PCRSpecies of hookwormXa activityPeptide-1Vaccine developmentHookworm Ancylostoma caninumA. ceylanicumAncylostoma ceylanicumHookwormAncylostoma caninumMitigation of Hookworm Disease by Immunization with Soluble Extracts of Ancylostoma ceylanicum
Bungiro R, Greene J, Kruglov E, Cappello M. Mitigation of Hookworm Disease by Immunization with Soluble Extracts of Ancylostoma ceylanicum. The Journal Of Infectious Diseases 2001, 183: 1380-1387. PMID: 11294670, DOI: 10.1086/319867.Peer-Reviewed Original ResearchConceptsHookworm infectionMajor clinical sequelaeHuman vaccine developmentCause of anemiaSyrian golden hamstersAdult worm burdenGlobal control effortsClinical sequelaeActive vaccinationPrimary infectionWorm burdenAdult hookwormsGrowth delayVaccine developmentHookworm diseaseGolden hamstersPooled seraAncylostoma ceylanicumPartial protectionAnemiaWeight lossAbsence of reductionInfectionAdult parasitesHamsters
1996
Molecular Approaches to Vaccinating against Hookworm Disease
Hotez P, Hawdon J, Cappello M, Jones B, Ghosh K, Volvovitz F, Shu-Hua X. Molecular Approaches to Vaccinating against Hookworm Disease. Pediatric Research 1996, 40: 515-521. PMID: 8888276, DOI: 10.1203/00006450-199610000-00001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLarval antigensVaccine antigensInfective hookworm larvaeProtective immunityHookworm infectionAdjuvant formulationsDrug chemotherapyAlternative vaccinesVaccine routeLive vaccineGenetic immunizationVaccine developmentHookworm larvaeHookworm diseaseParasitic diseasesAntigenPhase IVaccineAncylostoma caninumProtein 1ImmunizationTarget populationAcceptable approachDiseaseASP-2