Featured Publications
Comparison of percutaneous vs oral infection of hamsters with the hookworm Ancylostoma ceylanicum: Parasite development, pathology and primary immune response
Bungiro RD, Harrison LM, Dondji B, Cappello M. Comparison of percutaneous vs oral infection of hamsters with the hookworm Ancylostoma ceylanicum: Parasite development, pathology and primary immune response. PLOS Neglected Tropical Diseases 2022, 16: e0010098. PMID: 34986139, PMCID: PMC8765627, DOI: 10.1371/journal.pntd.0010098.Peer-Reviewed Original ResearchConceptsCellular immune responsesGolden Syrian hamstersImmune responsePercutaneous infectionOral infectionSyrian hamstersAncylostoma ceylanicumPrimary immune responseRoute of infectionModerate growth delayFaecal egg outputPercutaneous groupImmunological manifestationsAntibody titersHookworm Ancylostoma ceylanicumInfected hamstersWorm recoveryLarval antigensBlood hemoglobinDisease pathogenesisHost responseGrowth delayHuman infectionsInfectionA. ceylanicum
2019
Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana.
Orr AR, Quagraine JE, Suwondo P, George S, Harrison LM, Dornas FP, Evans B, Caccone A, Humphries D, Wilson MD, Cappello M. Genetic Markers of Benzimidazole Resistance among Human Hookworms (Necator americanus) in Kintampo North Municipality, Ghana. American Journal Of Tropical Medicine And Hygiene 2019, 100: 351-356. PMID: 30734697, PMCID: PMC6367626, DOI: 10.4269/ajtmh.18-0727.Peer-Reviewed Original ResearchConceptsMass drug administrationSoil-transmitted helminthsKintampo North MunicipalitySchool-aged childrenSingle nucleotide polymorphismsPolymerase chain reactionEffectiveness of MDAWild-type SNPsInfected study subjectsPeriodic mass drug administrationResistance-associated single nucleotide polymorphismsCross-sectional studyResistance-associated mutationsWorld Health OrganizationHookworm infectionDrug exposureHookworm eggsUnreported associationStudy subjectsDrug AdministrationPosttreatment samplesChemotherapeutic approachesGrowth delayHuman hookwormHealth Organization
2012
Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target
Treger R, Cook A, Rai G, Maloney D, Simeonov A, Jadhav A, Thomas C, Williams D, Cappello M, Vermeire J. Oxadiazole 2-oxides are toxic to the human hookworm, Ancylostoma ceylanicum, however glutathione reductase is not the primary target. International Journal For Parasitology Drugs And Drug Resistance 2012, 2: 171-177. PMID: 22844653, PMCID: PMC3404738, DOI: 10.1016/j.ijpddr.2012.05.001.Peer-Reviewed Original ResearchAncylostoma ceylanicumVivo anthelminthic efficacyIntestinal worm burdenEffective drug therapyGlutathione reductasePrimary targetOral treatmentSevere anemiaDrug therapyHookworm infectionHookworm Ancylostoma ceylanicumAntischistosomal compoundsHamster modelNovel chemotherapyTrematode parasite Schistosoma mansoniWorm burdenGrowth delayHookworm diseaseParasite Schistosoma mansoniEx vivoParasitic diseasesParasite deathA. ceylanicumSchistosoma mansoniWeight gain
2006
Dietary Iron Content Mediates Hookworm Pathogenesis In Vivo
Held MR, Bungiro RD, Harrison LM, Hamza I, Cappello M. Dietary Iron Content Mediates Hookworm Pathogenesis In Vivo. Infection And Immunity 2006, 74: 289-295. PMID: 16368983, PMCID: PMC1346670, DOI: 10.1128/iai.74.1.289-295.2006.Peer-Reviewed Original ResearchConceptsDay 20 postinfectionGrowth delayIron-restricted dietHigh-iron dietIntestinal worm burdenDietary iron restrictionIron deficiency anemiaBlood hemoglobin levelsDietary iron contentGreater weight lossSignificant growth delayHemoglobin levelsDeficiency anemiaHookworm infectionDiet groupHamster modelSevere diseaseStandard dietUninfected controlsHemoglobin concentrationUninfected animalsWorm burdenDay 10Infected animalsHookworm disease
2004
Hookworm infection: molecular mechanisms of disease and targets for control
Jones B, Cappello M. Hookworm infection: molecular mechanisms of disease and targets for control. Drug Discovery Today Disease Mechanisms 2004, 1: 217-222. DOI: 10.1016/j.ddmec.2004.10.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHookworm anaemiaSmall intestineMajor global health problemStage of diseaseGlobal health problemProtein-energy malnutritionVirulence factorsMolecular mechanismsPregnant womenSevere anemiaVaccine strategiesPlatelet inhibitorsPancreatic digestive enzymesHealth burdenEnergy malnutritionHost small intestineHealth problemsGrowth delayAnemiaHookworm diseaseIntestinal nematodesDisease controlChild mortalityMount Sinai SchoolPotential targetHookworm infection: new developments and prospects for control
Bungiro R, Cappello M. Hookworm infection: new developments and prospects for control. Current Opinion In Infectious Diseases 2004, 17: 421-426. PMID: 15353961, DOI: 10.1097/00001432-200410000-00006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHookworm infectionHookworm diseaseEffective global controlPathological immune responsesMajor health burdenParasite virulence factorsNew chemotherapeutic agentsDevelopment of vaccinesHookworm anaemiaImmunoepidemiological studiesMass chemotherapyHealth burdenImmune responseMolecular pathogenesisGrowth delayChemotherapeutic agentsInfectionVaccineSocioeconomic statusDiseaseVirulence factorsGlobal healthBenzimidazole anthelminthicsPathogenesisAnthelminthic resistanceMolecular Characterization of Ancylostoma ceylanicum Kunitz-Type Serine Protease Inhibitor: Evidence for a Role in Hookworm-Associated Growth Delay
Chu D, Bungiro RD, Ibanez M, Harrison LM, Campodonico E, Jones BF, Mieszczanek J, Kuzmic P, Cappello M. Molecular Characterization of Ancylostoma ceylanicum Kunitz-Type Serine Protease Inhibitor: Evidence for a Role in Hookworm-Associated Growth Delay. Infection And Immunity 2004, 72: 2214-2221. PMID: 15039345, PMCID: PMC375216, DOI: 10.1128/iai.72.4.2214-2221.2004.Peer-Reviewed Original ResearchConceptsGrowth delayAdult hookwormsIron deficiency anemiaPolyclonal immunoglobulin GDeficiency anemiaHookworm infectionReverse transcription-PCRKunitz-type serine protease inhibitorImmunohistochemistry studiesBroad-spectrum inhibitorPartial protectionMajor causeImmunoglobulin GSerine protease inhibitorIntestinal proteasesThird-stage larvaeTranscription-PCRProtease inhibitorsAnemiaHookwormVivo roleMalnutritionInhibitorsInfected hostPancreatic elastase
2001
Mitigation of Hookworm Disease by Immunization with Soluble Extracts of Ancylostoma ceylanicum
Bungiro R, Greene J, Kruglov E, Cappello M. Mitigation of Hookworm Disease by Immunization with Soluble Extracts of Ancylostoma ceylanicum. The Journal Of Infectious Diseases 2001, 183: 1380-1387. PMID: 11294670, DOI: 10.1086/319867.Peer-Reviewed Original ResearchConceptsHookworm infectionMajor clinical sequelaeHuman vaccine developmentCause of anemiaSyrian golden hamstersAdult worm burdenGlobal control effortsClinical sequelaeActive vaccinationPrimary infectionWorm burdenAdult hookwormsGrowth delayVaccine developmentHookworm diseaseGolden hamstersPooled seraAncylostoma ceylanicumPartial protectionAnemiaWeight lossAbsence of reductionInfectionAdult parasitesHamsters