2011
Streptococcus pneumoniae Clonal Complex 199: Genetic Diversity and Tissue-Specific Virulence
Thomas JC, Figueira M, Fennie KP, Laufer AS, Kong Y, Pichichero ME, Pelton SI, Pettigrew MM. Streptococcus pneumoniae Clonal Complex 199: Genetic Diversity and Tissue-Specific Virulence. PLOS ONE 2011, 6: e18649. PMID: 21533186, PMCID: PMC3077395, DOI: 10.1371/journal.pone.0018649.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChinchillaDisease Models, AnimalGenes, BacterialGenetic VariationPneumococcal InfectionsStreptococcus pneumoniaeVirulenceConceptsChinchilla modelHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineSerotype 19A isolatesMiddle ear isolatesS. pneumoniae isolatesLong-term effectivenessConjugate vaccinePneumococcal diseaseOtitis mediaVaccinated populationReplacement diseaseBlood isolatesInvasive diseaseCarriage isolatesPneumoniae isolatesCerebrospinal fluidEar isolatesFuture vaccinesImportant causeStreptococcus pneumoniaeMiddle earDiseaseVirulence potentialVaccine
2004
Prevalence of the hifBC, hmw1A, hmw2A, hmwC, and hia Genes in Haemophilus influenzae Isolates
Ecevit IZ, McCrea KW, Pettigrew MM, Sen A, Marrs CF, Gilsdorf JR. Prevalence of the hifBC, hmw1A, hmw2A, hmwC, and hia Genes in Haemophilus influenzae Isolates. Journal Of Clinical Microbiology 2004, 42: 3065-3072. PMID: 15243061, PMCID: PMC446296, DOI: 10.1128/jcm.42.7.3065-3072.2004.Peer-Reviewed Original ResearchConceptsAcute otitis mediaOtitis mediaH. influenzaeHia geneHaemophilus influenzaeMiddle earRespiratory tract sitesH. influenzae infectionsAdhesin genesClinical H. influenzaeThroat isolatesInfluenzae infectionNTHi isolatesNasopharyngeal colonizationNTHi strainsType b strainsClinical isolatesPrevalenceInfluenzaeB strainsEpithelial cellsHMW adhesinsType BVirulence factorsHib
2002
Identification of the Lipooligosaccharide Biosynthesis Gene lic2B as a Putative Virulence Factor in Strains of Nontypeable Haemophilus influenzae That Cause Otitis Media
Pettigrew M, Foxman B, Marrs C, Gilsdorf J. Identification of the Lipooligosaccharide Biosynthesis Gene lic2B as a Putative Virulence Factor in Strains of Nontypeable Haemophilus influenzae That Cause Otitis Media. Infection And Immunity 2002, 70: 3551-3556. PMID: 12065495, PMCID: PMC128108, DOI: 10.1128/iai.70.7.3551-3556.2002.Peer-Reviewed Original ResearchConceptsMiddle ear isolatesNT H. influenzaeOtitis mediaH. influenzaeEar isolatesThroat isolatesHaemophilus influenzaeMiddle earAcute otitis mediaDay careNontypeable Haemophilus influenzaeVirulence factorsSpecific virulence factorsType B isolatesOM pathogenesisPutative virulence factorsH. influenzae geneImportant causeClinical isolatesPathogenic processesInfluenzaeB isolatesAcid levelsAmino acid levelsNontypeable