2010
Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: Implications for the conjugate vaccine
Laufer AS, Thomas JC, Figueira M, Gent JF, Pelton SI, Pettigrew MM. Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: Implications for the conjugate vaccine. Vaccine 2010, 28: 2450-2457. PMID: 20067753, PMCID: PMC2851619, DOI: 10.1016/j.vaccine.2009.12.078.Peer-Reviewed Original ResearchConceptsSerotype 19ASerotype 15B/CChinchilla otitis media modelMiddle ear infectionOtitis media modelDisease prevention effortsStreptococcus pneumoniae isolatesExperimental otitis mediaStreptococcus pneumoniae serotypesQuantitative PCRConjugate vaccineOtitis mediaEar infectionsPneumoniae isolatesVaccine formulationsPneumoniae serotypesSame sequence typeVaccine targetsPrevention effortsPathogenic potentialDifferent serotypesSequence typesSerotypesIsolatesVaccine
2006
Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence Types
Pettigrew MM, Fennie KP, York MP, Daniels J, Ghaffar F. Variation in the Presence of Neuraminidase Genes among Streptococcus pneumoniae Isolates with Identical Sequence Types. Infection And Immunity 2006, 74: 3360-3365. PMID: 16714565, PMCID: PMC1479257, DOI: 10.1128/iai.01442-05.Peer-Reviewed Original ResearchConceptsPneumoniae isolatesSequence typesUpper respiratory tractNeuraminidase geneS. pneumoniae isolatesVirulence determinantsStreptococcus pneumoniae isolatesIdentical sequence typesYoung childrenAdditional virulence determinantsSialic acid-containing substratesCapsule typesMultilocus sequence typesOtitis mediaInvasive diseaseRespiratory tractCarriage isolatesPneumococcal clonesSame sequence typePneumococcal strainsImportant causeStreptococcus pneumoniaeMiddle earDifferent tissue sourcesPneumococcal neuraminidase