2018
Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats
Di QN, Cao WX, Xu R, Lu L, Xu Q, Wang XB. Chronic low-dose exposure of nonylphenol alters energy homeostasis in the reproductive system of female rats. Toxicology And Applied Pharmacology 2018, 348: 67-75. PMID: 29641977, DOI: 10.1016/j.taap.2018.04.007.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsCarnitine O-PalmitoyltransferaseEndocrine DisruptorsEndometrial HyperplasiaEndometriumEnergy MetabolismEstradiolFatty AcidsFemaleGlutathioneLiverMalondialdehydeMetabolomicsOogenesisOvaryOxidation-ReductionPhenolsPPAR gammaRats, Sprague-DawleyReproductionRisk AssessmentSuperoxide DismutaseConceptsFemale reproductive toxicityReproductive toxicityFemale ratsCarnitine palmitoyltransferase IEnergy homeostasisSerum 17β-estradiol levelsChronic low-dose exposurePeroxisome proliferator-activated receptor gammaImpaired fatty acid oxidationProliferator-activated receptor gammaReproductive systemHigh-dose exposureLow-dose exposureHuman exposure scenariosNP exposureFatty acid oxidationKey reproductive tissuesEndometrium hyperplasiaL-carnitineReceptor gammaPotential biomarkersComprehensive metabolomic studyEndocrine-disrupting chemicalsMetabolic profileDevelopmental toxicity
2017
Environmental factors, seven GWAS‐identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population
Cai M, Dai S, Chen W, Xia C, Lu L, Dai S, Qi J, Wang M, Wang M, Zhou L, Lei F, Zuo T, Zeng H, Zhao X. Environmental factors, seven GWAS‐identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population. Cancer Medicine 2017, 6: 708-720. PMID: 28220687, PMCID: PMC5345626, DOI: 10.1002/cam4.1038.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAMP-Activated Protein KinasesAntigens, NeoplasmAsian PeopleChinaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGPI-Linked ProteinsHelicobacter InfectionsHumansLogistic ModelsMaleMembrane Transport ProteinsMucin-1Neoplasm ProteinsNerve Tissue ProteinsRisk FactorsSmokingStomach NeoplasmsTranscription FactorsConceptsRisk of GCPylori infectionAlcohol drinkingPRKAA1 rs13361707Intestinal metaplasiaGastric cancerGene-environment interactionsGastric carcinogenesisChinese populationSevere intestinal metaplasiaHelicobacter pylori infectionUnconditional logistic regressionPrecancerous gastric lesionsGastric cancer riskEnvironmental risk factorsGenetic predisposition factorsGenome-wide association studiesSusceptibility lociMUC1 rs4072037Gastric lesionsRisk factorsEffect modificationCancer riskAlcohol consumptionDisease risk
2016
Metformin alters DNA methylation genome-wide via the H19/SAHH axis
Zhong T, Men Y, Lu L, Geng T, Zhou J, Mitsuhashi A, Shozu M, Maihle NJ, Carmichael GG, Taylor HS, Huang Y. Metformin alters DNA methylation genome-wide via the H19/SAHH axis. Oncogene 2016, 36: 2345-2354. PMID: 27775072, PMCID: PMC5415944, DOI: 10.1038/onc.2016.391.Peer-Reviewed Original ResearchConceptsS-adenosylhomocysteine hydrolaseDNA methylation genomeGenome-wide alterationsNovel mechanismSubset of genesDNA methyltransferase 3BMethylation genomeDNA methylationEpigenetic dysregulationPathway genesMolecular basisAMPK activationLet-7Methyltransferase 3BMolecular mechanismsEndometrial cancer tissue samplesH19 knockdownGene methylationCell proliferationCancer tissue samplesCancer cellsNormal cellsConcomitant inhibitionGenesMethylation