2022
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract
Zhou Y, Gu B, Brichant G, Singh JP, Yang H, Chang H, Zhao Y, Cheng C, Liu ZW, Alderman MH, Lu L, Yang X, Gao XB, Taylor HS. The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract. BMC Biology 2022, 20: 93. PMID: 35491423, PMCID: PMC9059368, DOI: 10.1186/s12915-022-01293-4.Peer-Reviewed Original ResearchConceptsEstrogen receptorMaintenance of pregnancyFetal mouse brainReproductive systemE3 micePregnancy outcomesEstrogen actionEstrogen potencyPregnant miceEstrogen exposureEstrogen signalingFetal developmentMouse brainSteroid hormonesUnexpected functional rolesPregnancyReproductive tractHormone estriolBrainReceptorsExpression levelsFetusesExploratory behaviorMiceNovel mechanism
2014
Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line
Hu X, Zhang J, Jiang Y, Lei Y, Lu L, Zhou J, Huang H, Fang D, Tao G. Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line. Toxicology In Vitro 2014, 28: 1377-1385. PMID: 25063376, DOI: 10.1016/j.tiv.2014.07.004.Peer-Reviewed Original ResearchConceptsPregnane X receptorThyroid receptorX receptorRegulation of CYP3A4Microsomal phase ITetra-bromodiphenyl etherHuman pregnane X receptorDual-luciferase reporterHepG2 cell modelBDE-47Human hepatoma cell lineDetailed underlying mechanismsMetabolic enzymesHepatoma cell lineThyroid hormonesBDE-47 treatmentToxicological evidencePhase IHealth effectsThyroid disruptionReceptorsExpression levelsHPXRUnderlying mechanismUGT1A3