Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models
Ganguly K, Nordström A, Thimraj TA, Rahman M, Ramström M, Sompa SI, Lin EZ, O’Brien F, Koelmel J, Ernstgård L, Johanson G, Pollitt KJG, Palmberg L, Upadhyay S. Addressing the challenges of E-cigarette safety profiling by assessment of pulmonary toxicological response in bronchial and alveolar mucosa models. Scientific Reports 2020, 10: 20460. PMID: 33235237, PMCID: PMC7686373, DOI: 10.1038/s41598-020-77452-w.Peer-Reviewed Original ResearchMeSH KeywordsBronchiCell Culture TechniquesCell LineElectronic Nicotine Delivery SystemsFlavoring AgentsGene Expression RegulationGenetic MarkersHumansModels, BiologicalNicotineParticle SizePulmonary AlveoliVapingConceptsElectronic cigarettesSafety profilingInjury/repairMucosa modelEpithelial barrier functionExpression of markersNicotine contentAnti-microbial defenseTissue injury/repairNicotine presenceHuman bronchialFlavoring agentBarrier functionLung modelOxidative stressEvidence-based policy recommendationsSignificant differencesRespiratory treeMulti-disciplinary approachLimited toxicity dataMultiple factorsAir-liquid interfaceSpecific roleToxicityCytotoxic compounds