2024
Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.
Ding E, Deng F, Fang J, Liu J, Yan W, Yao Q, Miao K, Wang Y, Sun P, Li C, Liu Y, Dong H, Dong L, Zhang X, Lu Y, Lin X, Ding C, Li T, Shi Y, Cai Y, Liu X, Godri Pollitt K, Ji J, Tong S, Tang S, Shi X. Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study. Environmental Health Perspectives 2024, 132: 97005. PMID: 39240788, PMCID: PMC11379127, DOI: 10.1289/ehp13864.Peer-Reviewed Original ResearchConceptsDyslipidemia markersCardiovascular diseaseMulti-omicsMarkers of dyslipidemiaExamination of cytokinesMeasurement of cytokinesSerum lipidomeSystemic inflammationMulti-omics profilingCardiac functionDyslipidemiaPrimary preventionClinical measuresSerumChinese adultsBlood transcriptomeImpact spectraCytokinesExposome-wide association studyInflammationMarkersBiomolecular pathwaysAssociationHealthy older adultsElectrocardiogram
2018
Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study
Liu L, Urch B, Szyszkowicz M, Evans G, Speck M, Van Huang A, Leingartner K, Shutt RH, Pelletier G, Gold DR, Brook JR, Godri Pollitt K, Silverman FS. Metals and oxidative potential in urban particulate matter influence systemic inflammatory and neural biomarkers: A controlled exposure study. Environment International 2018, 121: 1331-1340. PMID: 30420132, PMCID: PMC6396878, DOI: 10.1016/j.envint.2018.10.055.Peer-Reviewed Original ResearchConceptsUbiquitin C-terminal hydrolase L1Vascular endothelium growth factorBiomarker levelsPost exposureSystemic inflammationOxidative stressNeural biomarkersS100 calcium-binding protein BCalcium-binding protein BNeural functionHealthy non-smoking volunteersConcentrated ambient PMAssessment of biomarkersNon-smoking volunteersStress marker cortisolAmbient PMUrinary malondialdehydeUrinary biomarkersUrinary cortisolInterleukin-6Mixed regression modelsVanillylmandelic acidInflammationMean concentrationGrowth factor