2023
Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples
Lin E, Nason S, Zhong A, Fortner J, Godri Pollitt K. Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples. The Science Of The Total Environment 2023, 883: 163530. PMID: 37094673, PMCID: PMC10248884, DOI: 10.1016/j.scitotenv.2023.163530.Peer-Reviewed Original ResearchConceptsPolyfluoroalkyl substancesLiquid chromatography-high resolution mass spectrometryResolution mass spectrometryWater-repellent propertiesVenous blood samplesBlood samplesTrace levelsTrace analysisMass spectrometryWhole blood samplesChemical analysisAlkyl substancesHealthy adultsMan-made chemicalsAdverse health outcomesAnalytical methodBlank correctionHousehold productsHealth outcomesPFAS exposureInvasive methodBlood collectionBlood spotsCritical windowEnvironmental exposures
2021
The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study)
Tang S, Li T, Fang J, Chen R, Cha Y, Wang Y, Zhu M, Zhang Y, Chen Y, Du Y, Yu T, Thompson DC, Godri Pollitt KJ, Vasiliou V, Ji JS, Kan H, Zhang JJ, Shi X. The exposome in practice: an exploratory panel study of biomarkers of air pollutant exposure in Chinese people aged 60–69 years (China BAPE Study). Environment International 2021, 157: 106866. PMID: 34525388, DOI: 10.1016/j.envint.2021.106866.Peer-Reviewed Original ResearchConceptsAir pollutant exposurePotential adverse clinical outcomesPollutant exposureExploratory panel studyAdverse clinical outcomesHealthy elderly subjectsAdverse health outcomesAirborne pollutant exposureAir pollution exposureAdverse health effectsClinical outcomesModifiable factorsElderly subjectsHealthy residentsNovel biomarkersEndogenous exposureExogenous exposureHealth outcomesPotential biomarkersAirborne exposurePollution exposureSuboptimal assessmentAdverse health impactsAssociated biomarkersComprehensive biomarkerUse of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum
Jin L, Godri Pollitt KJ, Liew Z, Rosen Vollmar AK, Vasiliou V, Johnson CH, Zhang Y. Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum. Current Environmental Health Reports 2021, 8: 7-22. PMID: 33420964, DOI: 10.1007/s40572-020-00298-x.Peer-Reviewed Original ResearchConceptsAir pollutant exposureAdverse health effectsSpecific adverse health effectsOxidative stressHealth effectsPerturbation of metabolitesAir pollution exposureUntargeted metabolomicsPollutant exposureSteroid metabolic pathwaysPregnant womenInflammatory responseDisease continuumReviewThe purposeHealth outcomesLarger sample sizeMetabolic pathwaysDisease statusPollution exposureIdentified metabolitesMetabolic perturbationsMetabolic changesSummaryOur reviewAir pollution componentsMetabolomic analysis
2020
Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020
Anand M, Larsson K, Johanson G, Phuleria HC, Ravindra PV, Ernstgård L, Mabalirajan U, Krishna M, Palmberg L, Pollitt KJG, Upadhyay S, Ganguly K. Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020. Toxics 2020, 8: 68. PMID: 32899560, PMCID: PMC7560295, DOI: 10.3390/toxics8030068.Peer-Reviewed Original ResearchAdverse health effectsHealth effectsBiomass smoke exposureAdverse health outcomesPotential protective mechanismDeterminants of healthSmoke exposureEpidemiological field studiesHealth outcomesAdult cohortDietary exposureVivo modelProtective mechanismPersonalized exposure assessmentExposure assessmentStudy objectiveNew screening methodExposureMysuruMulti-disciplinary approachFuture studiesOutcomesSpecific aimScreening methodPlausible strategyAmbient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management
Gao D, Ripley S, Weichenthal S, Godri Pollitt KJ. Ambient particulate matter oxidative potential: Chemical determinants, associated health effects, and strategies for risk management. Free Radical Biology And Medicine 2020, 151: 7-25. PMID: 32430137, DOI: 10.1016/j.freeradbiomed.2020.04.028.Peer-Reviewed Original ResearchConceptsOxidative potentialRedox-active metalsRedox propertiesPM chemical constituentsOrganic speciesPM oxidative potentialTarget moleculesFine PM massOP assaysChemical constituentsChemical determinantsParticulate matter toxicityOP responseMass concentrationAssociated health effectsPM speciesAir pollution exposure assessmentMetalsEpidemiological studiesHealth outcomesEpidemiologic literaturePollution exposure assessmentHealth effectsRedoxExposure assessment
2013
PM2.5, oxidant defence and cardiorespiratory health: a review
Weichenthal SA, Godri Pollitt K, Villeneuve PJ. PM2.5, oxidant defence and cardiorespiratory health: a review. Environmental Health 2013, 12: 40. PMID: 23641908, PMCID: PMC3652795, DOI: 10.1186/1476-069x-12-40.Peer-Reviewed Original ResearchConceptsHealth effectsOxidant defenseAnti-oxidant related genesFurther evaluationOxidative stressCardiorespiratory health effectsLittle epidemiological evidenceAnti-oxidant supplementationPotential modifying roleAmbient air quality managementAcute health effectsImpact of polymorphismsHeart rate variabilityCardiorespiratory outcomesChronic outcomesRespiratory outcomesEpidemiological evidenceCardiorespiratory healthPM2.5 exposureHealth outcomesRate variabilityModifying roleExposure metricsOutcomesCommon outcome