2023
Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots
Koelmel J, Lin E, Parry E, Stelben P, Rennie E, Godri Pollitt K. Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots. The Science Of The Total Environment 2023, 883: 163579. PMID: 37100129, PMCID: PMC10247435, DOI: 10.1016/j.scitotenv.2023.163579.Peer-Reviewed Original ResearchConceptsBlood spotsNovel perfluoroalkyl substancesHuman bloodVenous blood drawBlood spot cardsBlood spot samplesPerfluoroalkyl substancesPrenatal exposureBlood drawEnvironmental epidemiology studiesEpidemiology studiesFalse negative rateBloodLow false negative rateInvasive collection techniquesWhole bloodVulnerable populationsLiquid chromatography-high resolution tandem mass spectrometryUnderstanding of exposureSpot samplesSpot cardsHigh-resolution tandem mass spectrometryExposurePerfluoroalkyl ether carboxylic acidsScreening
2022
Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential
Toyib O, Lavigne E, Traub A, Umbrio D, You H, Ripley S, Pollitt K, Shin T, Kulka R, Jessiman B, Tjepkema M, Martin R, Stieb DM, Hatzopoulou M, Evans G, Burnett RT, Weichenthal S. Long-term Exposure to Oxidant Gases and Mortality: Effect Modification by PM2.5 Transition Metals and Oxidative Potential. Epidemiology 2022, 33: 767-776. PMID: 36165987, PMCID: PMC9531968, DOI: 10.1097/ede.0000000000001538.Peer-Reviewed Original ResearchConceptsLong-term exposureOxidative stressFine particulate air pollutionProportional hazards modelAir pollution health effectsHealth impactsObserved health impactsParticulate air pollutionCohort studyMortality outcomesOxidant gasesEffect modificationInterquartile increaseHazards modelAdverse health impactsNonaccidental mortalityGSH levelsHealth effectsMortalityLand use regression modelsOxidative potentialMedianRegression modelsExposurePM 2.5Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort
DeLay K, Lin EZ, Koelmel JP, Bornman R, Obida M, Chevrier J, Godri Pollitt KJ. Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort. Environment International 2022, 170: 107524. PMID: 36260950, PMCID: PMC9982749, DOI: 10.1016/j.envint.2022.107524.Peer-Reviewed Original ResearchConceptsBirth cohortMalaria controlEnvironment (MACE) birth cohortVenda Health ExaminationEnvironmental exposuresBurden of diseaseIndoor residual sprayingSouth African childrenHousehold air pollutionMiddle-income countriesHealth examinationNon-invasive methodAfrican childrenPersonal exposure assessmentResidual sprayingExposure levelsPersonal exposureExposure assessmentExposure monitoringRural regionsChildrenHigh exposureEnvironmental contaminantsCohortExposureEmerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment
Jia X, Jin Q, Fang J, Shi Y, Hou M, Dong H, Liu Y, Deng F, Zhou Y, Pollitt K, Tang S, Shi X, Cai Y. Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment. Environmental Science And Technology 2022, 56: 7905-7916. PMID: 35584234, DOI: 10.1021/acs.est.2c00381.Peer-Reviewed Original ResearchConceptsElderly adultsHealthy elderly adultsBw/dayHuman exposureAdverse health effectsMedian intakeIntake assessmentElderly populationMonth assessment periodDietary ingestionHealth effectsInternal exposureWhole bloodPerfluorooctanoic acidExposure levelsImportant exposure pathwayExposure assessmentAssessment periodConsecutive monthsRegression analysisPolyfluoroalkyl substancesPerfluorooctanesulfonic acidCl-PFESAExposureAdultsAssessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study
Koelmel JP, Lin EZ, DeLay K, Williams AJ, Zhou Y, Bornman R, Obida M, Chevrier J, Pollitt K. Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study. Environmental Science And Technology 2022, 56: 2191-2203. PMID: 35089017, DOI: 10.1021/acs.est.1c06481.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryMass spectrometryAirborne chemical exposuresPassive samplersVenda Health ExaminationChemical exposureChildren's personal exposureSpectrometryPersonal exposureChemicalsMolecular levelSouth African childrenMiddle-income countriesHealth examinationExternal exposomeCombustion productsAfrican childrenAirborne chemicalsHealth effectsEnvironmental exposuresDyeAssessment periodPlasticizerExposureDichlorodiphenyldichloroethane
2020
Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020
Anand M, Larsson K, Johanson G, Phuleria HC, Ravindra PV, Ernstgård L, Mabalirajan U, Krishna M, Palmberg L, Pollitt KJG, Upadhyay S, Ganguly K. Clinical, Epidemiological and Experimental Approaches to Assess Adverse Health Outcomes of Indoor Biomass Smoke Exposure: Conclusions from An Indo-Swedish Workshop in Mysuru, January 2020. Toxics 2020, 8: 68. PMID: 32899560, PMCID: PMC7560295, DOI: 10.3390/toxics8030068.Peer-Reviewed Original ResearchAdverse health effectsHealth effectsBiomass smoke exposureAdverse health outcomesPotential protective mechanismDeterminants of healthSmoke exposureEpidemiological field studiesHealth outcomesAdult cohortDietary exposureVivo modelProtective mechanismPersonalized exposure assessmentExposure assessmentStudy objectiveNew screening methodExposureMysuruMulti-disciplinary approachFuture studiesOutcomesSpecific aimScreening methodPlausible strategyChapter sixteen Incorporating health impacts in transportation project decision-making in the United States
Christofa E, Esenther S, Pollitt K. Chapter sixteen Incorporating health impacts in transportation project decision-making in the United States. 2020, 343-369. DOI: 10.1016/b978-0-12-819136-1.00016-4.Peer-Reviewed Original Research
2019
Biodiesel fuels: A greener diesel? A review from a health perspective
Godri Pollitt K, Chhan D, Rais K, Pan K, Wallace JS. Biodiesel fuels: A greener diesel? A review from a health perspective. The Science Of The Total Environment 2019, 688: 1036-1055. PMID: 31726536, DOI: 10.1016/j.scitotenv.2019.06.002.Peer-Reviewed Original ResearchConceptsHealth effectsEffective public health policiesHuman exposure studiesPublic health policyEngine exhaustCardiovascular outcomesCardiopulmonary outcomesShort-term exposureExhaust exposureLung cellsHealth policyVivo studiesHealth benefitsHealth perspectiveExposure studiesHuman testingLow engineAftertreatment systemEngine characteristicsOutcomesParticulate emissionsRange of feedstocksExposureDieselAldehyde emissions
2018
Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust
Maikawa CL, Zimmerman N, Ramos M, Shah M, Wallace JS, Pollitt KJG. Comparison of Airway Responses Induced in a Mouse Model by the Gas and Particulate Fractions of Gasoline Direct Injection Engine Exhaust. International Journal Of Environmental Research And Public Health 2018, 15: 429. PMID: 29494515, PMCID: PMC5876974, DOI: 10.3390/ijerph15030429.Peer-Reviewed Original ResearchConceptsAirway hyperresponsivenessAllergic asthma murine modelAsthma murine modelNon-allergic miceMethacholine responsivenessAirway responsesPulmonary responsePeripheral tissuesMurine modelMouse modelShort-term exposureAcute exposureGDI engine exhaustPolycyclic aromatic hydrocarbon metabolismUpregulation of genesHyperresponsivenessParticulate fractionHealth impactsAromatic hydrocarbon metabolismPrevalenceMiceExposureDiesel exhaustAnimalsResponse
2017
BTEX exposure assessment and quantitative risk assessment among petroleum product distributors
Heibati B, Pollitt KJG, Karimi A, Charati J, Ducatman A, Shokrzadeh M, Mohammadyan M. BTEX exposure assessment and quantitative risk assessment among petroleum product distributors. Ecotoxicology And Environmental Safety 2017, 144: 445-449. PMID: 28666218, DOI: 10.1016/j.ecoenv.2017.06.055.Peer-Reviewed Original ResearchConceptsHigh-risk occupationsOccupational exposure limitsExcess riskCancer riskXylene exposureExcess lifetime cancer riskRisk occupationsHealth of workersGovernmental Industrial HygienistsLifetime cancer riskExposure assessmentExposure limitsIndustrial HygienistsRiskAmerican ConferenceExposureExposure samplesHazard quotientMean concentrationMaximum mean concentrationRisk assessmentMean valueQuantitative risk assessmentStrong contributorWorkers
2016
Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children
Godri Pollitt KJ, Maikawa CL, Wheeler AJ, Weichenthal S, Dobbin NA, Liu L, Goldberg MS. Trace metal exposure is associated with increased exhaled nitric oxide in asthmatic children. Environmental Health 2016, 15: 94. PMID: 27586245, PMCID: PMC5009709, DOI: 10.1186/s12940-016-0173-5.Peer-Reviewed Original ResearchConceptsAsthmatic childrenIQR increaseNitric oxideEmergency room visitsExacerbation of symptomsPersonal daily exposureAcute health effectsResultsA positive associationElevated FeNOFeNO responseAirway inflammationRoom visitsMarker of trafficDaily exposureAsthma experienceConsecutive daysFeNOChildren's exposureHealth effectsPersonal samplesChildrenPositive associationExposureFine particulate matterAmbient PM2.5Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions
Maikawa CL, Zimmerman N, Rais K, Shah M, Hawley B, Pant P, Jeong CH, Delgado-Saborit JM, Volckens J, Evans G, Wallace JS, Pollitt K. Murine precision-cut lung slices exhibit acute responses following exposure to gasoline direct injection engine emissions. The Science Of The Total Environment 2016, 568: 1102-1109. PMID: 27369091, DOI: 10.1016/j.scitotenv.2016.06.173.Peer-Reviewed Original ResearchConceptsLung slicesPulmonary responseBALB/c miceMurine precision-cut lung slicesOxidative stressPrecision-cut lung slicesOxidative stress markersOne-hour exposurePulmonary effectsC miceGDI engine exhaustAcute responseCYP1B1 expressionStress markersVivo modelPolycyclic aromatic hydrocarbon metabolismUpregulation of genesElectrostatic aerosolParticulate fractionAromatic hydrocarbon metabolismExposureUpregulated genesMRNA productionMetabolismAir-liquid interface