2023
Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
Manz K, Feerick A, Braun J, Feng Y, Hall A, Koelmel J, Manzano C, Newton S, Pennell K, Place B, Godri Pollitt K, Prasse C, Young J. Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 524-536. PMID: 37380877, PMCID: PMC10403360, DOI: 10.1038/s41370-023-00574-6.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryNon-targeted analysisExposure mediaChemical spaceSoils/sedimentsMass spectrometryPolyfluoroalkyl substancesSemi-volatile organic compoundsChemical exposomePolyaromatic hydrocarbonsLiquid chromatographyEnvironmental mediaOrganic compoundsGC-HRMSHuman exposureLC-HRMSAnalytical platformConsumer productsChemical exposureSedimentsPesticidesEnvironmental chemicalsChemicalsExposure sourcesSpectrometry
2022
Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study
Koelmel JP, Lin EZ, DeLay K, Williams AJ, Zhou Y, Bornman R, Obida M, Chevrier J, Pollitt K. Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study. Environmental Science And Technology 2022, 56: 2191-2203. PMID: 35089017, DOI: 10.1021/acs.est.1c06481.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryMass spectrometryAirborne chemical exposuresPassive samplersVenda Health ExaminationChemical exposureChildren's personal exposureSpectrometryPersonal exposureChemicalsMolecular levelSouth African childrenMiddle-income countriesHealth examinationExternal exposomeCombustion productsAfrican childrenAirborne chemicalsHealth effectsEnvironmental exposuresDyeAssessment periodPlasticizerExposureDichlorodiphenyldichloroethane
2021
Changes in Sewage Sludge Chemical Signatures During a COVID‐19 Community Lockdown, Part 2: Nontargeted Analysis of Sludge and Evaluation with COVID‐19 Metrics
Nason SL, Lin E, Pollitt K, Peccia J. Changes in Sewage Sludge Chemical Signatures During a COVID‐19 Community Lockdown, Part 2: Nontargeted Analysis of Sludge and Evaluation with COVID‐19 Metrics. Environmental Toxicology And Chemistry 2021, 41: 1193-1201. PMID: 34729807, PMCID: PMC8652773, DOI: 10.1002/etc.5226.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNACOVID-19COVID-19 case numbersHigh-resolution mass spectrometryChemical featuresHospital admissionEpidemiological metricsCase numbersEnviron Toxicol ChemCOVID-19 pandemicCOVID-19 metricsMass spectrometryIndicator compoundsIndicator moleculesMolecular weightFuture studiesLiquid chromatographyPresent studySewage sludge samplesNew HavenWastewaterAdmissionChemicalsInitial waveYale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS)
Hagstrom AL, Anastas P, Boissevain A, Borrel A, Deziel NC, Fenton SE, Fields C, Fortner JD, Franceschi-Hofmann N, Frigon R, Jin L, Kim JH, Kleinstreuer NC, Koelmel J, Lei Y, Liew Z, Ma X, Mathieu L, Nason SL, Organtini K, Oulhote Y, Pociu S, Godri Pollitt KJ, Saiers J, Thompson DC, Toal B, Weiner EJ, Whirledge S, Zhang Y, Vasiliou V. Yale School of Public Health Symposium: An overview of the challenges and opportunities associated with per- and polyfluoroalkyl substances (PFAS). The Science Of The Total Environment 2021, 778: 146192. PMID: 33714836, DOI: 10.1016/j.scitotenv.2021.146192.Peer-Reviewed Original ResearchHead, Shoulders, Knees, and Toes: Placement of Wearable Passive Samplers Alters Exposure Profiles Observed
Koelmel JP, Lin EZ, Nichols A, Guo P, Zhou Y, Pollitt K. Head, Shoulders, Knees, and Toes: Placement of Wearable Passive Samplers Alters Exposure Profiles Observed. Environmental Science And Technology 2021, 55: 3796-3806. PMID: 33625210, DOI: 10.1021/acs.est.0c05522.Peer-Reviewed Original ResearchConceptsSemivolatile organic compoundsOrganic compoundsGas chromatography-high resolution mass spectrometryPassive samplersHigh-resolution mass spectrometryVolatile organic compoundsPersonal exposure profilesChemicals of concernMass spectrometryChemicalsExposure dynamicsExposure profilesCompoundsMajor risk factorComprehensive characterizationPersonal exposureAirborne contaminantsContaminant exposureRisk factorsInhalation routeEpidemiological studiesChemical exposureSpectrometrySamplerParticipants' wrists
2020
Exploring the external exposome using wearable passive samplers - The China BAPE study
Koelmel JP, Lin EZ, Guo P, Zhou J, He J, Chen A, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Beecher C, Shi X, Tang S, Godri Pollitt KJ. Exploring the external exposome using wearable passive samplers - The China BAPE study. Environmental Pollution 2020, 270: 116228. PMID: 33360595, DOI: 10.1016/j.envpol.2020.116228.Peer-Reviewed Original ResearchConceptsPassive samplersPersonal care productsPersonal exposure profilesAirborne contaminant exposurePassive air samplersChemicals of concernToxicity of chemicalsPolyaromatic hydrocarbonsCare productsChina BAPE studyElevated toxicityPersonal exposureChemicalsSources of exposureParticulate phaseInhalation routeExternal exposomeGreater health risksCigarette smokeContaminant exposureAntimicrobial soapHealthy participantsRouteAir samplerEnvironmental exposuresDried blood spots for the identification of bioaccumulating organic compounds: Current challenges and future perspectives
Jobst KJ, Arora A, Pollitt KG, Sled JG. Dried blood spots for the identification of bioaccumulating organic compounds: Current challenges and future perspectives. Current Opinion In Environmental Science & Health 2020, 15: 66-73. PMID: 33073071, PMCID: PMC7560987, DOI: 10.1016/j.coesh.2020.07.001.Peer-Reviewed Original ResearchOrganic compoundsTrace level contaminantsAnalytical chemistryArt mass spectrometryMass spectrometryField of exposomicsChemical pollutantsMost environmental exposuresCompoundsCurrent challengesConstituent compoundsFuture perspectivesChemistryDBS analysisSpectrometryPollutantsExogenous chemicalsContaminantsChemicalsDry blood spotsExposomicsMixtureExposomeReliable approach