2023
Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome
Manz K, Feerick A, Braun J, Feng Y, Hall A, Koelmel J, Manzano C, Newton S, Pennell K, Place B, Godri Pollitt K, Prasse C, Young J. Non-targeted analysis (NTA) and suspect screening analysis (SSA): a review of examining the chemical exposome. Journal Of Exposure Science & Environmental Epidemiology 2023, 33: 524-536. PMID: 37380877, PMCID: PMC10403360, DOI: 10.1038/s41370-023-00574-6.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryNon-targeted analysisExposure mediaChemical spaceSoils/sedimentsMass spectrometryPolyfluoroalkyl substancesSemi-volatile organic compoundsChemical exposomePolyaromatic hydrocarbonsLiquid chromatographyEnvironmental mediaOrganic compoundsGC-HRMSHuman exposureLC-HRMSAnalytical platformConsumer productsChemical exposureSedimentsPesticidesEnvironmental chemicalsChemicalsExposure sourcesSpectrometry
2022
Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches
Shi W, Gao X, Cao Y, Chen Y, Cui Q, Deng F, Yang B, Lin E, Fang J, Li T, Tang S, Godri Pollitt K, Shi X. Personal airborne chemical exposure and epigenetic ageing biomarkers in healthy Chinese elderly individuals: Evidence from mixture approaches. Environment International 2022, 170: 107614. PMID: 36375280, DOI: 10.1016/j.envint.2022.107614.Peer-Reviewed Original ResearchConceptsEpigenetic ageing biomarkersPolycyclic aromatic hydrocarbonsOrganic chemical contaminantsVolatile organic compoundsElderly individualsChemical exposureAge-related adverse effectsBayesian kernel machine regression (BKMR) modelsOrganic compoundsAging biomarkersChinese elderly individualsOrganic chemicalsHealthy elderly peopleLinear mixed-effects regression modelsHealthy elderly individualsAirborne chemical exposuresQuantile sum (WQS) regressionPassive samplersNitroaromaticsMixed effects regression modelsEpigenetic biomarkersChemical contaminantsPersonal chemical exposureChlorinated hydrocarbonsChemical mixturesCharacterizing the external exposome using passive samplers—comparative assessment of chemical exposures using different wearable form factors
Lin EZ, Nichols A, Zhou Y, Koelmel JP, Godri Pollitt KJ. Characterizing the external exposome using passive samplers—comparative assessment of chemical exposures using different wearable form factors. Journal Of Exposure Science & Environmental Epidemiology 2022, 33: 558-565. PMID: 35840784, DOI: 10.1038/s41370-022-00456-3.Peer-Reviewed Original ResearchConceptsPassive air samplersGas chromatography-high resolution mass spectrometryPassive samplersHigh-resolution mass spectrometryResolution mass spectrometryAirborne organic contaminantsAirborne chemical contaminantsOrganic contaminantsChemical exposureMass spectrometryAir samplerChemical contaminantsPersonal chemical exposureAirborne contaminantsActive samplersPersonal exposureContaminantsType of exposureSampler positionsEpidemiological studiesAirborne exposureExternal exposomeHousehold productsChestEnvironmental exposuresAssessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study
Koelmel JP, Lin EZ, DeLay K, Williams AJ, Zhou Y, Bornman R, Obida M, Chevrier J, Pollitt K. Assessing the External Exposome Using Wearable Passive Samplers and High-Resolution Mass Spectrometry among South African Children Participating in the VHEMBE Study. Environmental Science And Technology 2022, 56: 2191-2203. PMID: 35089017, DOI: 10.1021/acs.est.1c06481.Peer-Reviewed Original ResearchConceptsHigh-resolution mass spectrometryMass spectrometryAirborne chemical exposuresPassive samplersVenda Health ExaminationChemical exposureChildren's personal exposureSpectrometryPersonal exposureChemicalsMolecular levelSouth African childrenMiddle-income countriesHealth examinationExternal exposomeCombustion productsAfrican childrenAirborne chemicalsHealth effectsEnvironmental exposuresDyeAssessment periodPlasticizerExposureDichlorodiphenyldichloroethane
2021
50 chemical exposures of concern discovered using wearable passive samplers and gas chromatography high-resolution mass spectrometry in South African children
Koelmel J, Lin E, Delay K, Williams A, Zhou Y, Bornman R, Obida M, Chevrier J, Godri Pollitt K. 50 chemical exposures of concern discovered using wearable passive samplers and gas chromatography high-resolution mass spectrometry in South African children. ISEE Conference Abstracts 2021, 2021 DOI: 10.1289/isee.2021.o-lt-106.Peer-Reviewed Original ResearchExploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China
Guo P, Lin EZ, Koelmel JP, Ding E, Gao Y, Deng F, Dong H, Liu Y, Cha Y, Fang J, Shi X, Tang S, Godri Pollitt KJ. Exploring personal chemical exposures in China with wearable air pollutant monitors: A repeated-measure study in healthy older adults in Jinan, China. Environment International 2021, 156: 106709. PMID: 34153889, DOI: 10.1016/j.envint.2021.106709.Peer-Reviewed Original ResearchConceptsVolatile organic compoundsPolycyclic aromatic hydrocarbonsAirborne chemical contaminantsPersonal exposure profilesPassive air samplersOrganic compoundsPassive samplersChemical classesChemical contaminantsChemical analysisPersonal chemical exposureCertain polycyclic aromatic hydrocarbonsChemical exposureAirborne compoundsAirborne contaminantsCompoundsAromatic hydrocarbonsContaminantsAir monitoring sitesComprehensive characterizationPhthalateNitroaromaticsRepeated-measures studyAir samplerNitrobenzeneHead, Shoulders, Knees, and Toes: Placement of Wearable Passive Samplers Alters Exposure Profiles Observed
Koelmel JP, Lin EZ, Nichols A, Guo P, Zhou Y, Pollitt K. Head, Shoulders, Knees, and Toes: Placement of Wearable Passive Samplers Alters Exposure Profiles Observed. Environmental Science And Technology 2021, 55: 3796-3806. PMID: 33625210, DOI: 10.1021/acs.est.0c05522.Peer-Reviewed Original ResearchConceptsSemivolatile organic compoundsOrganic compoundsGas chromatography-high resolution mass spectrometryPassive samplersHigh-resolution mass spectrometryVolatile organic compoundsPersonal exposure profilesChemicals of concernMass spectrometryChemicalsExposure dynamicsExposure profilesCompoundsMajor risk factorComprehensive characterizationPersonal exposureAirborne contaminantsContaminant exposureRisk factorsInhalation routeEpidemiological studiesChemical exposureSpectrometrySamplerParticipants' wrists