Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity
Jayasundara D, Gamage C, Senavirathna I, Warnasekara J, Matthias MA, Vinetz J, Agampodi S. Optimizing the microscopic agglutination test (MAT) panel for the diagnosis of Leptospirosis in a low resource, hyper-endemic setting with varied microgeographic variation in reactivity. PLOS Neglected Tropical Diseases 2021, 15: e0009565. PMID: 34197457, PMCID: PMC8279374, DOI: 10.1371/journal.pntd.0009565.Peer-Reviewed Original ResearchHeterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Rosado J, White MT, Longley RJ, Lacerda M, Monteiro W, Brewster J, Sattabongkot J, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Gamboa D, Mueller I. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. PLOS Neglected Tropical Diseases 2021, 15: e0009165. PMID: 33591976, PMCID: PMC7909627, DOI: 10.1371/journal.pntd.0009165.Peer-Reviewed Original ResearchConceptsSerological exposure markersBlood-stage infectionLow transmission settingsP. vivax infectionPlasmodium vivax infectionHigh transmission settingsVivax infectionTransmission settingsAntibody titersAntibody responseExposure markersDifferent transmission intensitiesIgG responsesSerological markersPrevious infectionReceiver Operating Characteristic (ROC) analysisEndemic settingsMalaria eliminationPeruvian cohortOperating characteristics analysisP. vivaxMalaria controlRecent exposureInfectionEpidemiological context