2022
Relative contribution of low-density and asymptomatic infections to Plasmodium vivax transmission in the Amazon: pooled analysis of individual participant data from population-based cross-sectional surveys
Ferreira MU, Corder RM, Johansen IC, Kattenberg JH, Moreno M, Rosas-Aguirre A, Ladeia-Andrade S, Conn JE, Llanos-Cuentas A, Gamboa D, Rosanas-Urgell A, Vinetz JM. Relative contribution of low-density and asymptomatic infections to Plasmodium vivax transmission in the Amazon: pooled analysis of individual participant data from population-based cross-sectional surveys. The Lancet Regional Health - Americas 2022, 9: 100169. PMID: 35663000, PMCID: PMC9161731, DOI: 10.1016/j.lana.2021.100169.Peer-Reviewed Original ResearchIndividual participant dataPolymerase chain reactionClinical manifestationsParasite densityMosquito infectionMalaria transmissionPopulation-based cross-sectional surveyParticipant dataMalaria elimination strategiesPopulation-based surveyHigh parasite densityCross-sectional surveyInfected childrenClinical symptomsAsymptomatic infectionUS National InstitutesAsymptomatic carriersParasite carriersInfectious reservoirVivax transmissionInfectionFundação de Amparo à PesquisaChain reactionNational InstituteElimination strategy
2016
Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia
Fontoura PS, Finco BF, Lima NF, de Carvalho JF, Vinetz JM, Castro MC, Ferreira MU. Reactive Case Detection for Plasmodium vivax Malaria Elimination in Rural Amazonia. PLOS Neglected Tropical Diseases 2016, 10: e0005221. PMID: 27941968, PMCID: PMC5179126, DOI: 10.1371/journal.pntd.0005221.Peer-Reviewed Original ResearchConceptsMalaria eliminationIndex caseElimination effortsControl householdsCorrelates of infectionReactive case detectionMixed-effects logistic regression modelResidual malaria transmissionCase detection strategiesMolecular genotypingMalaria elimination effortsP. vivax transmissionTotal parasite biomassReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionLogistic regression modelsP. vivax diversityPotential confoundersAsymptomatic carriersPolymerase chain reactionCase detectionIndex householdsQPCR-positive samplesMalaria burdenPlasmodium vivax