2023
Multimodeling approach to evaluating the efficacy of layering pharmaceutical and nonpharmaceutical interventions for influenza pandemics
Prasad P, Steele M, Reed C, Meyers L, Du Z, Pasco R, Alfaro-Murillo J, Lewis B, Venkatramanan S, Schlitt J, Chen J, Orr M, Wilson M, Eubank S, Wang L, Chinazzi M, Pastore y Piontti A, Davis J, Halloran M, Longini I, Vespignani A, Pei S, Galanti M, Kandula S, Shaman J, Haw D, Arinaminpathy N, Biggerstaff M. Multimodeling approach to evaluating the efficacy of layering pharmaceutical and nonpharmaceutical interventions for influenza pandemics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2300590120. PMID: 37399393, PMCID: PMC10334766, DOI: 10.1073/pnas.2300590120.Peer-Reviewed Original ResearchMeSH KeywordsAntiviral AgentsHumansInfluenza VaccinesInfluenza, HumanPandemicsPharmaceutical PreparationsConceptsInfluenza pandemicPandemic influenza scenarioOverall disease burdenIntervention strategiesPandemic influenza modelsNumber of illnessesAntiviral treatmentEffective intervention strategiesDisease burdenPopulation infectionVaccine developmentDisease controlSchool closuresNonpharmaceutical interventionsInfluenza modelVirus spreadEarly spreadEarly implementationPandemic scenarioUniversity of VirginiaHospitalizationPandemicVaccinationGroupVaccine
2019
Future epidemiological and economic impacts of universal influenza vaccines
Sah P, Alfaro-Murillo JA, Fitzpatrick MC, Neuzil KM, Meyers LA, Singer BH, Galvani AP. Future epidemiological and economic impacts of universal influenza vaccines. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 20786-20792. PMID: 31548402, PMCID: PMC6789917, DOI: 10.1073/pnas.1909613116.Peer-Reviewed Original ResearchConceptsUniversal influenza vaccineDirect health care costsInfluenza vaccineSeasonal vaccineUniversal vaccineHealth care costsCare costsInfluenza-related deathsVaccines actVaccine mismatchRapid antigenic evolutionInfluenza transmissionVaccine developmentVaccineInfectious diseasesPopulation-level impactElderly residentsMedical expensesNational InstituteHospitalizationAntigenic evolutionDeathEfficacyLarge proportionAllergy
2013
A deterministic model for influenza infection with multiple strains and antigenic drift
Alfaro-Murillo JA, Towers S, Feng Z. A deterministic model for influenza infection with multiple strains and antigenic drift. Journal Of Biological Dynamics 2013, 7: 199-211. PMID: 23701386, PMCID: PMC3780334, DOI: 10.1080/17513758.2013.801523.Peer-Reviewed Original ResearchMeSH KeywordsAntigenic VariationComputer SimulationHumansInfluenza, HumanModels, BiologicalOrthomyxoviridaePhylogenyPrevalence