2024
Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India
Shah D, Bhide S, Deshmukh R, Smith J, Kaiplyawar S, Puri V, Yeldandi V, Date A, Nyendak M, Ho C, Moonan P. Test and treat approach for tuberculosis infection amongst household contacts of drug-susceptible pulmonary tuberculosis, Mumbai, India. Frontiers In Tuberculosis 2024, 2: 1454277. PMID: 39421397, PMCID: PMC11485165, DOI: 10.3389/ftubr.2024.1454277.Peer-Reviewed Original ResearchInterferon-gamma release assayTB preventive treatmentTB infectionHousehold contactsDrug-susceptible pulmonary tuberculosisTB diseaseTreat approachProgression to active TB diseaseDrug-susceptible pulmonary TBRate of TB infectionPrevalence of TB infectionActive TB diseaseAge 5 yearsSecondary TB casesCross-sectional studyAntituberculosis treatmentIGRA testPulmonary TBPulmonary tuberculosisTuberculosis infectionInterferon-gammaRelease assayClinical evaluationEarly diagnosisTreat strategyExhaled breath analysis: A promising triage test for tuberculosis in young children
Bijker E, Smith J, Mchembere W, McCarthy K, Oord H, Gerritsen J, Click E, Cain K, Song R. Exhaled breath analysis: A promising triage test for tuberculosis in young children. Tuberculosis 2024, 149: 102566. PMID: 39332067, DOI: 10.1016/j.tube.2024.102566.Peer-Reviewed Original ResearchTriage testPaediatric pulmonary tuberculosisRespiratory tract infectionsSymptoms of tuberculosisDiagnose respiratory tract infectionsCross-sectional studyExpectorated sputumTract infectionsPulmonary tuberculosisPaediatric tuberculosisDiagnostic accuracyBreath testYoung childrenYoung infantsTuberculosisExhaled breath analysisBreathingBreath analysisChildrenTriageExhaled breathSputumInfantsFeasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children
Khambati N, Song R, Smith J, Bijker E, McCarthy K, Click E, Mchembere W, Okumu A, Musau S, Okeyo E, Perez-Velez C, Cain K. Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children. Diagnostic Microbiology And Infectious Disease 2024, 109: 116302. PMID: 38657352, PMCID: PMC11128341, DOI: 10.1016/j.diagmicrobio.2024.116302.Peer-Reviewed Original Research
2023
Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis
Gunasekera K, Marcy O, Muñoz J, Lopez-Varela E, Sekadde M, Franke M, Bonnet M, Ahmed S, Amanullah F, Anwar A, Augusto O, Aurilio R, Banu S, Batool I, Brands A, Cain K, Carratalá-Castro L, Caws M, Click E, Cranmer L, García-Basteiro A, Hesseling A, Huynh J, Kabir S, Lecca L, Mandalakas A, Mavhunga F, Myint A, Myo K, Nampijja D, Nicol M, Orikiriza P, Palmer M, Sant'Anna C, Siddiqui S, Smith J, Song R, Thuong Thuong N, Ung V, van der Zalm M, Verkuijl S, Viney K, Walters E, Warren J, Zar H, Marais B, Graham S, Debray T, Cohen T, Seddon J. Development of treatment-decision algorithms for children evaluated for pulmonary tuberculosis: an individual participant data meta-analysis. The Lancet Child & Adolescent Health 2023, 7: 336-346. PMID: 36924781, PMCID: PMC10127218, DOI: 10.1016/s2352-4642(23)00004-4.Peer-Reviewed Original ResearchConceptsTreatment decision algorithmsPrimary health care settingsIndividual participant dataHigh tuberculosis incidencePulmonary tuberculosisManagement of tuberculosisHealth care centersComposite reference standardHealth care settingsClinical featuresTuberculosis incidenceClinical evaluationParticipant dataTreatment decisionsChest X-ray featuresPrimary health care centersFuture prospective evaluationTuberculosis-related mortalityEvidence-based algorithmChest X-rayVariable diagnostic performanceMultivariable prediction modelReference standardEvidence-based approachTuberculosis experts
2019
Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis
Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu MD, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP. Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis. Clinical Infectious Diseases 2019, 70: 1845-1854. PMID: 31242296, PMCID: PMC7156779, DOI: 10.1093/cid/ciz560.Peer-Reviewed Original ResearchConceptsPositron emission tomography-computed tomographyHuman immunodeficiency virusTotal glycolytic activityAntiretroviral therapyART initiationLung functionPulmonary tuberculosisLung inflammationLung injuryPulmonary inflammationMycobacteria-specific CD4 T cellsFluorodeoxyglucose positron emission tomography-computed tomographyCD4 T-cell restorationCD4 T cell functionCD4 T cell responsesEmission tomography-computed tomographyHuman immunodeficiency virus/tuberculosisTB treatment completionT-cell restorationWorse lung functionProspective cohort studyHIV/tuberculosisCD4 T cellsFDG PET-CTT cell responses