Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis
Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu MD, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP. Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis. Clinical Infectious Diseases 2019, 70: 1845-1854. PMID: 31242296, PMCID: PMC7156779, DOI: 10.1093/cid/ciz560.Peer-Reviewed Original ResearchConceptsPositron emission tomography-computed tomographyHuman immunodeficiency virusTotal glycolytic activityAntiretroviral therapyART initiationLung functionPulmonary tuberculosisLung inflammationLung injuryPulmonary inflammationMycobacteria-specific CD4 T cellsFluorodeoxyglucose positron emission tomography-computed tomographyCD4 T-cell restorationCD4 T cell functionCD4 T cell responsesEmission tomography-computed tomographyHuman immunodeficiency virus/tuberculosisTB treatment completionT-cell restorationWorse lung functionProspective cohort studyHIV/tuberculosisCD4 T cellsFDG PET-CTT cell responses