2020
The Impact of Concurrent Antiretroviral Therapy and MDR-TB Treatment on Adverse Events.
Smith JP, Gandhi NR, Shah NS, Mlisana K, Moodley P, Johnson BA, Allana S, Campbell A, Nelson KN, Master I, Brust JCM. The Impact of Concurrent Antiretroviral Therapy and MDR-TB Treatment on Adverse Events. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 83: 47-55. PMID: 31809360, PMCID: PMC6903405, DOI: 10.1097/qai.0000000000002190.Peer-Reviewed Original ResearchConceptsMultidrug-resistant tuberculosisConcurrent antiretroviral therapyMDR-TB patientsMDR-TB treatmentLaboratory adverse eventsAdverse eventsHIV coinfectionAntiretroviral therapyHIV statusConcurrent treatmentCommon clinical adverse eventsCommon laboratory adverse eventsCo-infected participantsColor discrimination testingMDR-TB therapyAntiretroviral therapy initiationFrequent adverse eventsClinical adverse eventsProspective observational studyFavorable treatment outcomesColor discrimination lossesTherapy initiationConcurrent therapyCreatinine clearanceVision loss
2019
Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis
Ravimohan S, Auld SC, Maenetje P, Ratsela N, Mlotshwa M, Ncube I, Smith JP, Vangu MD, Sebe M, Kossenkov A, Weissman D, Wallis RS, Churchyard G, Kornfeld H, Bisson GP. Lung Injury on Antiretroviral Therapy in Adults With Human Immunodeficiency Virus/Tuberculosis. Clinical Infectious Diseases 2019, 70: 1845-1854. PMID: 31242296, PMCID: PMC7156779, DOI: 10.1093/cid/ciz560.Peer-Reviewed Original ResearchConceptsPositron emission tomography-computed tomographyHuman immunodeficiency virusTotal glycolytic activityAntiretroviral therapyART initiationLung functionPulmonary tuberculosisLung inflammationLung injuryPulmonary inflammationMycobacteria-specific CD4 T cellsFluorodeoxyglucose positron emission tomography-computed tomographyCD4 T-cell restorationCD4 T cell functionCD4 T cell responsesEmission tomography-computed tomographyHuman immunodeficiency virus/tuberculosisTB treatment completionT-cell restorationWorse lung functionProspective cohort studyHIV/tuberculosisCD4 T cellsFDG PET-CTT cell responses
2017
Improved Survival and Cure Rates With Concurrent Treatment for Multidrug-Resistant Tuberculosis–Human Immunodeficiency Virus Coinfection in South Africa
Brust JCM, Shah NS, Mlisana K, Moodley P, Allana S, Campbell A, Johnson BA, Master I, Mthiyane T, Lachman S, Larkan LM, Ning Y, Malik A, Smith JP, Gandhi NR. Improved Survival and Cure Rates With Concurrent Treatment for Multidrug-Resistant Tuberculosis–Human Immunodeficiency Virus Coinfection in South Africa. Clinical Infectious Diseases 2017, 66: 1246-1253. PMID: 29293906, PMCID: PMC5888963, DOI: 10.1093/cid/cix1125.Peer-Reviewed Original ResearchConceptsCells/mm3Immunodeficiency virus coinfectionAntiretroviral therapyMDR tuberculosisCD4 countVirus coinfectionConcurrent treatmentTreatment outcomesHuman immunodeficiency virus (HIV) coinfectionUndetectable HIV viral loadConcurrent antiretroviral therapyMDR tuberculosis patientsHIV viral loadMultidrug-resistant tuberculosisStrong risk factorTuberculosis-HIVTuberculosis outcomesAdverse eventsTuberculosis patientsImproved survivalMedian agePrimary outcomeHIV statusViral loadCure rate